a, b highlight the log2 fold change and -log10 false discovery rate (FDR) of the differentially expressed genes from the author’s original work (Mathys et al.) and our reanalysis (Our analysis). In b, we have marked an FDR of 5x10-7, dashed grey line, to highlight how small the p-values from Mathys et al.’s analysis are. c, d, e, f, g show the Pearson correlation between the cell counts after QC and the number of DEGs identified. For f, g analysis, the samples have been randomly mixed between case and control patients. The different cell types are astrocytes (Astro), excitatory neurons (Exc), inhibitory neurons (Inh), microglia (Micro), oligodendrocytes (Oligo) and oligodendrocyte precursor cells (OPC).