Prevalence of anti-SARS-CoV-2 Spike S1 and -NCP antibo-dies in Bolivia as October 2021 and June 2022.

The prevalence of anti-SARS-CoV-2 Spike S1 (A, C) and -NCP (B, D) antibodies was reported for each department in Bolivia and nationwide as October 2021 (A, B) and June 2022 (C, D).

Prevalence of neutralizing anti-SARS-CoV-2 antibodies in Bolivia as October 2021 and June 2022.

The prevalence of neutralizing antibodies was reported for each department in Bolivia and nationwide for the D614G (A, E), Gamma (B, F), Delta (C, G) and Omicron BA.1 (D, H) variants as October 2021 (upper panel: A, B, C, D) and June 2022 (lower panel: E, F, G, H). The prevalence was obtained with the positivity cut-off ≥640.

Variant circulation in Bolivia as October 2021 and June 2022.

Percentage of the population exhibiting titers for Gamma, Delta, and Omicron BA.1 being at least equivalent to (log2-ratios ≤0, upper panel: A, B, C, D), twice (log2-ratios ≤-1, middle panel: E, F, G, H), or four times (log2-ratios ≤-2, lower panel: I, J, K, L) that of D614G are presented for each department of Bolivia. Results for D614G/γ are depicted in blue as October 2021 (A, E, I) and June 2022 (B, F, J). Results obtained as June 2022 for D614G/δ and for D614G/ο are depicted in green (C, G, K) and in red (D, H, L), respectively. D614G: ancestral D614G variant; γ: Gamma variant; δ: Delta variant; ο: Omicron BA.1 variant.

Quantification of SARS-CoV-2 circulating antigenic groups in Bolivia by Average titer method as October 2021 and as June 2022.

Percentage of the population in each department presenting a neutralizing antibody response against a defined antigenic group, including the GI (green), GII (blue), GIII (red), using the Average titer method. For antigenic group assignment by VNT, D614G and Delta variants were cluster in to the antigenic group I (GI), antigenic group II (GII) corresponded to the Gamma variant, while antigenic group III (GIII) was defined by the Omicron BA.1 variant (see methods for details). For evaluating genomic data, the prevalences of GI (from ances-tral, Alpha, Delta, Lambda, and Epsilon variants; light-green), the prevalences of GII (from Beta, Gamma, Mu, Iota, and Zeta variants; light-blue), and the prevalences of GIII (from all Omicron-derived variants; light-red) were obtained for neighboring countries of Bolivia using publicly accessible genomic data when available.