A practical toolbox for application of Granger causality inference to calcium imaging data identifies strong driver neurons in the locus of the mesencephalic locomoter region in larval zebrafish.
Molecular and spatial profiling methods idenified five neuronal subtypes that are distributed along the anteroposterior axis of the paraventricular thalamus, a structure increasingly implicated in the control of emotional and motivated behaviors.
In cortical pyramidal neurons, subtype-specific SUMOylation of Na+ channels regulates input-output relationships, synaptic boosting, and action potential propagation from the axonal trigger zone back into the dendrites.
For the first time, the strength of homeostatic plasticity has been shown to be negatively regulated and the transcription factors responsible for this regulation have been identified.
Christoph Wiest, Flavie Torrecillos ... Huiling Tan
The slope of the power spectrum of subthalamic local field potentials tracks pathological states in Parkinson’s disease and likely complements beta activity as a feedback marker for adaptive deep brain stimulation.
BDNF-regulated deployment of Rab10 to the distal axon regulates retrograde propagation of neurotrophic signalling, providing a flexible mechanism to fine-tune the communication between the synapse and the cell body of neurons, as well as novel therapeutic targets for neurodegeneration.
Janine Traut, Jose Prius Mengual ... Lukas B Krone
The two most commonly used chemogenetic actuators, clozapine-N-oxide and compound 21, similarly modulate sleep in wild-type laboratory mice indicating that even designer drugs which do not convert to clozapine can elicit behavioural effects and require adequate controls.
Ryszard Stefan Gomolka, Lauren M Hablitz ... Yuki Mori
Mice with aquaporin-4 channel deletion exhibit larger interstitial spaces, brain volume and water content, alongside reduced CSF space volume, which may increased resistance towards brain fluid efflux and suppress glymphatic flow.
