A versatile computational framework realistically simulates fluorescence lifetime data in biological systems, enhancing rigor by quantifying signal variance and identifying limitations, and enabling innovations such as multiplexed dynamic biosensor imaging.
The substantia nigra inhibits all PPN neurons and causes place aversion, while the globus pallidus selectively inhibits caudal non-cholinergic PPN neurons and causes place preference.
Maria Ardaya, Marie-Catherine Tiveron ... Fabio Cavaliere
A population of ischemia-induced newborn astrocytes, positive for Thbs4, that migrate to the lesion border, where they produce and degrade hyaluronan, modulating the local extracellular matrix, has been identified.
Souleymane Diallo, Kateřina Kašparová ... Robert Hanus
Identification of the trail-following pheromone receptor in the termite Prorhinotermes simplex represents the first functional characterization (deorphanization) of an odorant receptor in termites.
Rosanna P Sammons, Stefano Masserini ... Dietmar Schmitz
The asymmetric connectivity between thorny and athorny pyramidal neurons in the CA3 region is the key in maintaining the separation of peak firing during sharp wave events.
Population trajectories of premotor cortex mirror neurons progress through distinct subspaces during execution versus observation of reach-grasp-manipulate movements, yet latent dynamics can be aligned, indicating similar relationships among neural representations.
Ruggiero Francavilla, Bidisha Chattopadhyaya ... Graziella Di Cristo
Syngap1 haploinsufficiency, which is associated with intellectual disability, epilepsy, and other cognitive and behavioral impairments, reduces the firing and excitatory drive of cortical interneurons.
