(A) The 36 facial feature points annotated by the automatic image analysis algorithm. Supra-orbital ridge (8 points), the eyes (mid points of the eyelids and eye canthi, 8 points), nose (nasion, tip, ala, subnasale and outer nares, 7 points), mouth (vermilion border lateral and vertical midpoints, 6 points), and the jaw (zygoma mandibular border, gonion, mental protrubance and chin midpoint, 7 points). (B) The annotation accuracies relative to the manually annotated ground truth of each of the computer vision modules. Points 1–8 refer to the supra-orbital ridge, points 30–36 refer to the jaw points. Accuracies for the points annotated by the modules FLA, improved FLA and CoE are shown for each syndrome and control groups. Accuracies are shown as the average error relative to the width of an eye.