1. Developmental Biology and Stem Cells
  2. Neuroscience
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Delivery of circulating lipoproteins to specific neurons in the Drosophila brain regulates systemic Insulin signaling

  1. Marko Brankatschk Is a corresponding author
  2. Sebastian Dunst
  3. Linda Nemetschke
  4. Suzanne Eaton
  1. Max Planck Institute for Molecular Cell Biology and Genetics, Germany
Research Article
Cited
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Cite as: eLife 2014;3:e02862 doi: 10.7554/eLife.02862

Abstract

The Insulin signaling pathway couples growth, development and lifespan to nutritional conditions. Here, we demonstrate a function for the Drosophila lipoprotein LTP in conveying information about dietary lipid composition to the brain to regulate Insulin signaling. When yeast lipids are present in the diet, free calcium levels rise in Blood Brain Barrier glial cells. This induces transport of LTP across the Blood Brain Barrier by two LDL receptor-related proteins: LRP1 and Megalin. LTP accumulates on specific neurons that connect to cells that produce Insulin-like peptides, and induces their release into the circulation. This increases systemic Insulin signaling and the rate of larval development on yeast-containing food compared with a plant-based food of similar nutritional content.

Article and author information

Author details

  1. Marko Brankatschk

    1. Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany
    For correspondence
    1. brankats@mpi-cbg.de
    Competing interests
    The authors declare that no competing interests exist.
  2. Sebastian Dunst

    1. Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany
    Competing interests
    The authors declare that no competing interests exist.
  3. Linda Nemetschke

    1. Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany
    Competing interests
    The authors declare that no competing interests exist.
  4. Suzanne Eaton

    1. Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany
    Competing interests
    The authors declare that no competing interests exist.

Reviewing Editor

  1. Mani Ramaswami, Reviewing Editor, Trinity College Dublin, Ireland

Publication history

  1. Received: March 24, 2014
  2. Accepted: October 1, 2014
  3. Accepted Manuscript published: October 2, 2014 (version 1)
  4. Version of Record published: October 28, 2014 (version 2)

Copyright

© 2014, Brankatschk et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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