1. Stem Cells and Regenerative Medicine
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Quiescence: Quantitative differences, qualitative outcomes

  1. Giulia Pollarolo
  2. Cayetano Gonzalez  Is a corresponding author
  1. Juan de la Cierva Fellow and is in the Institute for Research in Biomedicine, Spain
  2. Institució Catalana de Recerca i Estudis Avançats (ICREA) and the Institute for Research in Biomedicine, Spain
Cite this article as: eLife 2014;3:e04869 doi: 10.7554/eLife.04869
1 figure


In neuroblasts, the amount of a protein called Prospero controls the behaviour of the cell.

Drosophila embryonic neuroblasts undergo asymmetric cell division—which produces a ganglion mother cell and a renewed neuroblast—when the level of Prospero (indicated by the blue triangle) is minimal (left). Low levels of Prospero drive proliferating neuroblasts into quiescence (middle). Quiescent neuroblasts can become proliferative again in response to a nutrition-dependent signal produced by an organ in the larva called the fat body. High levels of Prospero force proliferating neuroblasts to differentiate and become a specialized neural cell (right).

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