Stem Cells and Regenerative Medicine

Stem Cells and Regenerative Medicine

eLife reviews research on stem cell function, organogenesis, and tissue regeneration. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Stem Cells and Regenerative Medicine

    Chromatin activity of IκBα mediates the exit from naïve pluripotency

    Luis G Palma, Daniel Álvarez-Villanueva ... Anna Bigas
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    The Drosophila hematopoietic niche assembles through collective cell migration controlled by neighbor tissues and Slit-Robo signaling

    Kara A Nelson, Kari F Lenhart ... Stephen DiNardo
    A new example of niche formation, revealing the mode of niche cell migration, implicates extrinsic sources of positional information, and uncovers the pathway required for stereotypical positioning of the niche.
    1. Stem Cells and Regenerative Medicine

    Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathway

    Ryosuke Isotani, Masaki Igarashi ... Toshimasa Yamauchi
    Nicotine affects intestinal stem cells rather than Paneth cells, resulting in the increased stemness and tumorigenicity of intestinal stem cells.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    A novel human pluripotent stem cell gene activation system identifies IGFBP2 as a mediator in the production of haematopoietic progenitors in vitro

    Paolo Petazzi, Telma Ventura ... Antonella Fidanza
    A novel tool is used to assess gene function in vitro by targeted endogenous transcriptional activation to unveil novel players in development and disease.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Base editing of Ptbp1 in neurons alleviates symptoms in a mouse model of Parkinson’s disease

    Desiree Böck, Maria Wilhelm ... Gerald Schwank
    Downregulation of PTBP1 in neurons, but not astrocytes, alleviates motor symptoms in a Parkinson’s disease mouse model by inducing dopaminergic marker expression in striatal neurons and increasing striatal dopamine levels.
    1. Stem Cells and Regenerative Medicine

    Rejuvenating aged osteoprogenitors for bone repair

    Joshua Reeves, Pierre Tournier ... Shukry J Habib
    Short-term interventions, including intermittent fasting, boosting cellular energy, and promoting beneficial gut bacteria, rejuvenate osteoprogenitors in aged animals and, when combined with localized Wnt, restore youthful bone healing.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    A multiplexed, single-cell sequencing screen identifies compounds that increase neurogenic reprogramming of murine Muller glia

    Amy Tresenrider, Marcus Hooper ... Thomas A Reh
    An in vitro chemical screen with single-cell sequencing output leads to the identification of Metformin as an in vivo enhancer of Muller glia to neuron reprogramming in mice.
    1. Stem Cells and Regenerative Medicine

    Pharmacologically inducing regenerative cardiac cells by small molecule drugs

    Wei Zhou, Kezhang He ... Sheng Ding
    Induction of regenerative cardiac cells (RCCs) from human embryonic stem cell-derived cardiomyocytes and neonatal rat cardiomyocytes using a novel two-compound treatment enhances heart function following myocardial infarction and offers a promising avenue for cardiac regeneration through transcriptional and epigenetic reprogramming.

Senior editors

  1. Utpal Banerjee
    University of California, Los Angeles, United States
  2. Lynne-Marie Postovit
    University of Alberta, Canada
  3. Lori Sussel
    University of Colorado Anschutz Medical Campus, United States
  4. See more editors