Stem Cells and Regenerative Medicine

Stem Cells and Regenerative Medicine

eLife reviews research on stem cell function, organogenesis, and tissue regeneration. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Stem Cells and Regenerative Medicine

    Endometrial epithelial cells with high ALDH activity control uterine development and regeneration

    Suni Tang, Anna Catherine Unser ... Diana Monsivais
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Human adherent cortical organoids in a multi-well format

    Mark van der Kroeg, Sakshi Bansal ... Femke MS de Vrij
    Human stem cell-derived adherent cortical organoids in 384-well plates provide a reproducible, long-term cortical organoid platform with neurons, glia, and robust network activity, enabling scalable disease modeling and therapeutic screening.
    1. Stem Cells and Regenerative Medicine

    Synergistic Inhibition of Notch Signaling and Forced Cell Cycle Re-entry Drive Müller Glia Reprogramming in Uninjured Mouse Retina

    Baoshan Liao, Chengshang Lyu ... Wenjun Xiong
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Patient-Specific Midbrain Organoids with CRISPR Correction Recapitulate Neuronopathic Gaucher Disease Phenotypes and Enable Evaluation of Novel Therapies

    Yi Lin, Benjamin Liou ... Ying Sun
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    • Solid
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Adrenomedullin restores the human cortical interneurons migration defects induced by hypoxia

    Alyssa Puno, Wojciech P Michno ... Anca M Pasca
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    A developmentally regulated long-range enhancer-promoter contact mediates human neural development

    Devin Bready, Shuai Wang ... Dimitris G Placantonakis
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Stem Cells and Regenerative Medicine

    Rejuvenation-Responsive and Senolytic-Sensitive Muscle Stem Cells Unveiled by CD200 and CD63 in Geriatric Muscle

    Ye Lynne Kim, Young-Woo Jo ... Young-Yun Kong
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Stem Cells and Regenerative Medicine

    Proteome dynamics reveal Leiomodin 1 as a key regulator of myogenic differentiation

    Ellen Späth, Svenja C Schüler ... Alessandro Ori
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Branched actin polymerization drives invasive protrusion formation to promote myoblast fusion during mouse skeletal muscle regeneration

    Yue Lu, Tezin Walji ... Elizabeth H Chen
    Branched actin cytoskeleton is critical for myoblast fusion during mouse skeletal muscle regeneration.
    Version of Record
    Short Report
    • Valuable
    • Convincing
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors

    Abdulkadir Ozkan, Hari K Padmanabhan ... Jeffrey D Macklis
    Developmentally-based directed differentiation from cortical progenitors sets a foundation for in vitro mechanistic and therapeutic disease modeling, and toward regenerative neuronal repopulation and circuit repair.
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Highlights

    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Cardiac Repair: Aiming for spatial and temporal control of gene expression

    Stanislao Igor Travisano, Ching-Ling Lien
    1. Stem Cells and Regenerative Medicine

    Cell Death: Caspases promote cell proliferation after necrosis

    Prathibha Yarikipati, Andreas Bergmann
    1. Stem Cells and Regenerative Medicine

    Immune Cells: Growing microglia in the lab

    Jonathan M Levenson, Hio Tong Kam, Dong Feng Chen

Senior editors

  1. Sofia J Araújo
    University of Barcelona, Spain
  2. Sonia Q Sen
    Tata Institute for Genetics and Society, India
  3. Lori Sussel
    University of Colorado Anschutz Medical Campus, United States
  4. See more editors