Stem Cells and Regenerative Medicine

Latest articles

1. 1. Stem Cells and Regenerative Medicine

   Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing

   Fu Yang et al.

   A Drosophila fertility gene is identified that acts as a linker between HP1a and local H3K4 demethylation during HP1a-mediated gene silencing that is required for ovary development and transposon silencing..
2. 1. Genetics and Genomics
   2. Stem Cells and Regenerative Medicine

   Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons

   Chongyuan Luo et al.

   Induced neuronal cells acquire epigenomic signatures specific to matured neurons.
3. 1. Stem Cells and Regenerative Medicine

   Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass

   Bo Shen et al.
4. 1. Genetics and Genomics
   2. Stem Cells and Regenerative Medicine

   The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders

   Cheen Euong Ang et al.
5. 1. Stem Cells and Regenerative Medicine

   Stem cells repurpose proliferation to contain a breach in their niche barrier

   Kenneth Lay et al.

   Adult stem cells sense nearby tissue damage and recruit immune cells to help them direct efforts towards containing a breach in the epithelial barrier.
6. 1. Stem Cells and Regenerative Medicine

   Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation

   Lucy LeBlanc et al.

   During ES cell differentiation, Yap1 directly regulates apoptosis-related genes like Bcl-2 and Mcl-1 to attenuate apoptosis and promote cell survival to allow for successful cell fate changes.
7. 1. Stem Cells and Regenerative Medicine

   Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging

   Petter Säwen et al.

   Using a lineage tracing model, it is demonstrated that adult murine hematopoiesis is contingent on the continuous output from HSCs, with quantitative contributions that are dependent on lineage-type and age.
8. 1. Stem Cells and Regenerative Medicine

   Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

   Diego Balboa et al.

   Mutations causing proinsulin misfolding trigger unfolded protein response and lead to impaired proliferation and reduced mTORC1 signalling of developing beta-cells in a patient-derived induced pluripotent stem cell disease model.
9. 1. Human Biology and Medicine
   2. Stem Cells and Regenerative Medicine

   Insulin: Folding mutations suppress early beta-cell proliferation

   Honey Modi, James D Johnson

   Exploring how proliferation and maturation of beta-cells can be impaired after birth will shed light on the origins of various forms of diabetes.
10. 1. Stem Cells and Regenerative Medicine

    Long-term live imaging of the Drosophila adult midgut reveals real-time dynamics of division, differentiation and loss

    Judy Lisette Martin et al.

    A new platform for imaging live Drosophila adults yields vivid movies of the midgut over prolonged time scales, opening the door to the real-time study of organ renewal dynamics in a near-native context.