Stem Cells and Regenerative Medicine

Stem Cells and Regenerative Medicine

eLife publishes research on stem cell function, organogenesis, and tissue regeneration. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    The C. elegans gonadal sheath Sh1 cells extend asymmetrically over a differentiating germ cell population in the proliferative zone

    Xin Li, Noor Singh ... Kacy Lynn Gordon
    As Caenorhabditis elegans adult hermaphrodite germ cells leave the stem cell niche, they associate with a pair of somatic gonad cells that were thought to be symmetrical, but that actually take on dramatically different positions in the organ.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Transcriptional heterogeneity and cell cycle regulation as central determinants of Primitive Endoderm priming

    Marta Perera, Silas Boye Nissen ... Joshua M Brickman
    The simultaneous expansion of G1 and acceleration of the cell cycle, while ensuring synchronous inheritance of these properties, progressively induces cell identity in differentiation.
    1. Stem Cells and Regenerative Medicine

    A regeneration-triggered metabolic adaptation is necessary for cell identity transitions and cell cycle re-entry to support blastema formation and bone regeneration

    Ana S Brandão, Jorge Borbinha ... Antonio Jacinto
    Zebrafish caudal fin amputation induces an increase in the glycolytic influx that leads to dedifferentiation of osteoblasts and their re-entry in the cell cycle, which is essential for blastema formation and bone regeneration.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Defining the ultrastructure of the hematopoietic stem cell niche by correlative light and electron microscopy

    Sobhika Agarwala, Keun-Young Kim ... Owen J Tamplin
    Multiple imaging modalities resolved the ultrastructure of single hematopoietic stem cells in their endogenous niche, allowing identification of dopamine beta-hydroxylase positive cells as a functional niche cell type.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Development: Shining a light on hematopoietic stem cells

    Anne Schmidt
    A combination of light and electron microscopy has revealed further details about the location and interactions of hematopoietic stem and progenitor cells.
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    1. Stem Cells and Regenerative Medicine

    Generation of functional hepatocytes by forward programming with nuclear receptors

    Rute A Tomaz, Ekaterini D Zacharis ... Ludovic Vallier
    Forward programming of human pluripotent stem cells with a combination of four transcription factors allows the production of functional hepatocytes.

Senior editors

  1. Utpal Banerjee
    University of California, Los Angeles, United States
  2. Marianne E Bronner
    Marianne E Bronner
    California Institute of Technology, United States
  3. Edward Morrisey
    University of Pennsylvania, United States
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