Stem Cells and Regenerative Medicine

Latest articles

1. 1. Human Biology and Medicine
   2. Stem Cells and Regenerative Medicine

   Persistent epigenetic memory impedes rescue of the telomeric phenotype in human ICF iPSCs following DNMT3B correction

   Shir Toubiana et al.

   Correction of the DNA methyltransferase 3B gene in ICF1 syndrome fails to rescue the abnormal DNA hypomethylation at subtelomeric regions due to accompanied epigenetic abnormalities in these regions.
2. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration

   Dana Gancz et al.

   Cardiac lymphatic vessels of heterogeneous origins and molecular signatures support cardiac growth and regeneration.
3. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Late developing cardiac lymphatic vasculature supports adult zebrafish heart function and regeneration

   Michael RM Harrison et al.

   Zebrafish develop cardiac lymphatic vessels along coronary arteries and this vasculature supports scar reduction following severe damage to the myocardium.
4. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Screening identifies small molecules that enhance the maturation of human pluripotent stem cell-derived myotubes

   Sridhar Selvaraj et al.

   Treatment of human pluripotent stem cell-derived myotubes with a cocktail of small molecules induces their maturation, as shown by gene expression, biochemical and functional assays.
5. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Regeneration: Lymphatic vessels help mend broken hearts

   Catherine Pfefferli, Anna Jaźwińska

   Experiments on zebrafish show that the regeneration of the heart after an injury depends on lymphatic vessels.
6. 1. Neuroscience
   2. Stem Cells and Regenerative Medicine

   Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells

   Isabelle Maria Blomfield et al.

   Genetic and protein analyses in vitro and in vivo identifies Id4 as a novel regulator of stem cell quiescence in the adult hippocampus.
7. 1. Computational and Systems Biology
   2. Stem Cells and Regenerative Medicine

   Self-assembling manifolds in single-cell RNA sequencing data

   Alexander J Tarashansky et al.

   An iterative self-assembling algorithm identifies the intrinsic structures in single-cell transcriptomic data and helps to discover new cell populations that are undetectable by existing methods.
8. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   A distinct transition from cell growth to physiological homeostasis in the tendon

   Mor Grinstein et al.

   Mitotic labeling defines a change in cell division kinetics from growth to homeostasis and identifies slowly cycling cells in the adult tendon.
9. 1. Human Biology and Medicine
   2. Stem Cells and Regenerative Medicine

   Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

   Kevin Achberger et al.

   A microphysiological system (retina-on-a-chip) shows the potential to promote drug development and provide new insights into the underlying pathology of retinal diseases.
10. 1. Human Biology and Medicine
    2. Stem Cells and Regenerative Medicine

    Tissue Engineering: Building a better model of the retina

    Milica Radisic

    Researchers have combined organ-on-a-chip engineering with the benefits of organoids to make improved models of the human retina.