Stem Cells and Regenerative Medicine

Stem Cells and Regenerative Medicine

eLife reviews research on stem cell function, organogenesis, and tissue regeneration. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Stem Cells and Regenerative Medicine

    Regeneration: How the liver keeps itself in shape

    Stephanie May, Thomas G Bird
    After fasting, hepatocytes proliferate to help the liver grow back to its original size.
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    1. Stem Cells and Regenerative Medicine

    Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver

    Abby Sarkar, Yinhua Jin ... Roel Nusse
    Hepatocytes proliferate to maintain a constant liver-to-body mass ratio during intermittent fasting.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Differential chondrogenic differentiation between iPSC derived from healthy and OA cartilage is associated with changes in epigenetic regulation and metabolic transcriptomic signatures

    Nazir M Khan, Martha Elena Diaz-Hernandez ... Hicham Drissi
    The iPSCs derived from OA cartilage showed memory of disease which affect its chondrogenic potential and regulation at epigenetic and metabolic level may be used to control the regenerative potential of these iPSCs.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Mir155 regulates osteogenesis and bone mass phenotype via targeting S1pr1 gene

    Zhichao Zheng, Lihong Wu ... Janak L Pathak
    Mir155 showed a catabolic effect on osteogenesis and bone mass phenotype via interaction with the S1pr1 gene, suggesting inhibition of Mir155 as a potential approach to bone regeneration and bone defect healing.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Germline/soma distinction in Drosophila embryos requires regulators of zygotic genome activation

    Megan M Colonnetta, Paul Schedl, Girish Deshpande
    Components of zygotic genome activation, Zelda and CLAMP, contribute to the proper specification of primordial germ cells in Drosophila embryos.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals

    Amrita A Iyer, Ishwar Hosamani ... Andrew K Groves
    Cells of the mammalian cochlea can be reprogrammed to produce mechanosensory hair cells, but epigenetic changes in the cochlea make this process less efficient with age.
    1. Stem Cells and Regenerative Medicine

    High-resolution imaging of the osteogenic and angiogenic interface at the site of murine cranial bone defect repair via multiphoton microscopy

    Kevin Schilling, Yuankn Zhai ... Xinping Zhang
    High-resolution multiphoton microscopy reveals coupling of blood vessel subtype with expanding osteoblasts at the bone regeneration interface, further highlighting the heterogeneity of oxygen microenvironment and its impact on cellular energy metabolism of bone and vessel forming cells.

Senior editors

  1. Utpal Banerjee
    University of California, Los Angeles, United States
  2. Marianne E Bronner
    Marianne E Bronner
    California Institute of Technology, United States
  3. Edward Morrisey
    University of Pennsylvania, United States
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