Stem Cells and Regenerative Medicine

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Stem Cells and Regenerative Medicine

   MicroRNA-deficient mouse embryonic stem cells acquire a functional interferon response

   Jeroen Witteveldt et al.

   MiRNA-mediated suppression of MAVS expression in embryonic stem cells is necessary to inactivate the type I interferon response.
2. 1. Stem Cells and Regenerative Medicine

   Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons

   Joseph Herdy et al.

   An unbiased RNAseq based strategy to identify targetable pathways and a streamlined lentiviral system provide a state of the art advance on direct fibroblast to neuron conversion.
3. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Hierarchical stem cell topography splits growth and homeostatic functions in the fish gill

   Julian Stolper et al.
4. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction

   Mohsen Afshar Bakooshli et al.

   Human skeletal muscle progenitors and motor neurons self-organize in three-dimensional co-culture to form functional neuromuscular junctions that developmentally mature from the embryonic to the adult state.
5. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Myonuclear accretion is a determinant of exercise-induced remodeling in skeletal muscle

   Qingnian Goh et al.

   Fusion of muscle progenitors drives continuous myonuclear accretion during exercise and impacts various adaptations in skeletal muscle including response to injury and hypertrophy.
6. 1. Stem Cells and Regenerative Medicine

   Nuclear receptor NR4A is required for patterning at the ends of the planarian anterior-posterior axis

   Dayan J Li et al.
7. 1. Stem Cells and Regenerative Medicine

   Sox9+ messenger cells orchestrate large-scale skeletal regeneration in the mammalian rib

   Stephanie T Kuwahara et al.

   Large-scale skeletal regeneration requires Hh signaling in Sox9+ lineage cells to coordinate callus formation and bone repair.
8. 1. Stem Cells and Regenerative Medicine

   Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade

   Emily J Lodge et al.

   The LATS/YAP/TAZ cascade promotes SOX2+ pituitary stem cell fate and when over-activated, transforms normal stem cells into cancer stem cells.
9. 1. Computational and Systems Biology
   2. Stem Cells and Regenerative Medicine

   Single cell RNA-seq identifies the origins of heterogeneity in efficient cell transdifferentiation and reprogramming

   Mirko Francesconi et al.

   Variation in efficiency, speed and path during transdifferentiation and reprogramming originates from two pre-B cell subpopulations with reciprocal propensity towards each fate conversion.
10. 1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Distinct progenitor populations mediate regeneration in the zebrafish lateral line

    Eric D Thomas, David W Raible

    The zebrafish lateral line utilizes multiple, genetically distinct, independently regulated progenitors to generate new hair cells during homeostasis and regeneration, and to maintain progenitor pools.