Stem Cells and Regenerative Medicine

Stem Cells and Regenerative Medicine

eLife reviews research on stem cell function, organogenesis, and tissue regeneration. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Stem Cells and Regenerative Medicine

    Synergistic inhibition of Notch signaling and forced cell cycle re-entry drive Müller glia reprogramming in uninjured mouse retina

    Baoshan Liao, Chengshang Lyu ... Wenjun Xiong
    Stimulating cell cycle entry and suppressing Notch signaling drive mammalian Müller glia to proliferate and generate diverse, long-surviving neuron-like cells, offering insights into overcoming retinal regeneration barriers.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Direct lineage conversion of postnatal mouse cortical astrocytes to oligodendrocyte lineage cells

    Justine Bajohr, Erica Y Scott ... Maryam Faiz
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Convincing
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Galectin and Myc enable cochlear progenitor expansion in vitro and in vivo

    Marie Kubota, Julia M Abitbol ... Stefan Heller
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Nutrient Microenvironments Reprogram Pigment Epithelium Metabolism and Phenotype

    Rayne R Lim, Emily Zhao ... Jennifer R Chao
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    The bile acid receptor TGR5 is a modulator of bone marrow adipose tissue and the hematopoietic niche

    Alejandro Alonso-Calleja, Alessia Perino ... Olaia Naveiras
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Combinatorial transcription factor interactions drive modular gene regulatory networks

    Jialei Duan, Boxun Li ... Gary C Hon
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Stem Cells and Regenerative Medicine

    Endometrial cells with high ALDH activity contribute to uterine development and regeneration

    Suni Tang, Anna Catherine Unser ... Diana Monsivais
    ALDH1A1+ cells are a group of hormone-sensitive stem cells that contribute to endometrial development and repair.
    1. Stem Cells and Regenerative Medicine

    Proteome dynamics reveal Leiomodin 1 as a key regulator of myogenic differentiation

    Ellen Späth, Svenja C Schüler ... Alessandro Ori
    Leiomodin 1 acts as a critical molecular switch during early muscle stem cell differentiation by sequestering the deacetylase SIRT1 in the cytoplasm to initiate the myogenic program.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Arrayed single-gene perturbations identify drivers of human anterior neural tube closure

    Roya E Huang, Giridhar M Anand ... Sharad Ramanathan
    A method for arrayed CRISPRi screening in organoids enables the investigation of morphogenesis in human stem cell-derived tissues, revealing the roles of ZIC2, SOX11, and ZNF521 in neural tube closure.

Senior editors

  1. Lynne-Marie Postovit
    University of Alberta, Canada
  2. Sonia Q Sen
    Tata Institute for Genetics and Society, India
  3. Lori Sussel
    University of Colorado Anschutz Medical Campus, United States
  4. See more editors