Stem Cells and Regenerative Medicine

Latest articles

1. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids

   Anna Yoney et al.

   The requirement for WNT signaling in mesendoderm differentiation is temporally separate from that of ACTIVIN signaling and acts to switch the output of ACTIVIN/SMAD2 from pluripotency maintenance to mesendoderm patterning.
2. 1. Stem Cells and Regenerative Medicine
   2. Developmental Biology

   Hair follicle epidermal stem cells define a niche for tactile sensation

   Chun-Chun Cheng et al.

   Heterogeneous epidermal stem cells define a niche for tactile sensation via providing a unique ECM and tissue architecture for nerves, revealing their new functions in coordinated sensory organ formation.
3. 1. Stem Cells and Regenerative Medicine

   Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

   Diego Balboa et al.
4. 1. Cancer Biology
   2. Stem Cells and Regenerative Medicine

   T-ALL leukemia stem cell 'stemness' is epigenetically controlled by the master regulator SPI1

   Haichuan Zhu et al.
5. 1. Neuroscience
   2. Stem Cells and Regenerative Medicine

   Engineering induction of singular neural rosette emergence within hPSC-derived tissues

   Gavin T Knight et al.

   A bioengineering approach identifies tissue morphology as an effective variable for controlling the inception of neural organoid morphogenesis via induction of a biomimetic, singular neural rosette tissue cytoarchitecture.
6. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Altered bone growth dynamics prefigure craniosynostosis in a zebrafish model of Saethre-Chotzen syndrome

   Camilla S Teng et al.

   Sequential live imaging of abnormal skull bone fusion in zebrafish reveals a deeply conserved role of two transcription factors, Twist1 and Tcf12, in regulating stem cell activity during growth of the skull.
7. 1. Cell Biology
   2. Stem Cells and Regenerative Medicine

   The role of Pitx2 and Pitx3 in muscle stem cells gives new insights into P38α MAP kinase and redox regulation of muscle regeneration

   Aurore L'honoré et al.

   Modulation of muscle stem cell redox state in culture both improves their amplification while maintaining a similar grafting potential as freshly isolated stem cells.
8. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference

   Ashley RG Libby et al.

   Dynamic control of intrinsic pluripotent multicellular self-organization to yield robust symmetry breaking patterns that recapitulate morphogenic processes associated with developmental events.
9. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Cellular localization of the cell cycle inhibitor Cdkn1c controls growth arrest of adult skeletal muscle stem cells

   Despoina Mademtzoglou et al.

   Ablation of the Cdkn1c cell cycle inhibitor leads to defective muscle stem cell dynamics and myogenic potential, while progressive cytoplasmic to nuclear cellular localization of the Cdkn1c protein regulates growth arrest.
10. 1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    YAP drives cutaneous squamous cell carcinoma formation and progression

    Zoé Vincent-Mistiaen et al.

    High levels of nuclear YAP are sufficient to drive squamous cell carincoma formation and frequently also drive progression to spindle cell carcinoma by promoting epithelial-to-mesenchymal transition after tissue damage.