Stem Cells and Regenerative Medicine

Stem Cells and Regenerative Medicine

eLife publishes research on stem cell function, organogenesis, and tissue regeneration. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals

    Amrita A Iyer, Ishwar Hosamani ... Andrew K Groves
    Cells of the mammalian cochlea can be reprogrammed to produce mechanosensory hair cells, but epigenetic changes in the cochlea make this process less efficient with age.
    1. Stem Cells and Regenerative Medicine

    High-resolution imaging of the osteogenic and angiogenic interface at the site of murine cranial bone defect repair via multiphoton microscopy

    Kevin Schilling, Yuankn Zhai ... Xinping Zhang
    High-resolution multiphoton microscopy reveals coupling of blood vessel subtype with expanding osteoblasts at the bone regeneration interface, further highlighting the heterogeneity of oxygen microenvironment and its impact on cellular energy metabolism of bone and vessel forming cells.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Mettl3-mediated m6A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration

    Fu-Qing Jiang, Kun Liu ... Xu-Feng Qi
    Mettl3 post-transcriptionally reduces Fgf16 mRNA levels through an m6A-Ythdf2-dependen pathway, thereby controlling cardiomyocyte proliferation and heart regeneration.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing

    Wenbo Liu, Xukun Lu ... Jianqiao Liu
    SRSF10 directly binds genes functioning in spermatogonia and regulates their alternative splicing, the defect of which can lead to progenitor expansion failure.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Vinculin recruitment to α-catenin halts the differentiation and maturation of enterocyte progenitors to maintain homeostasis of the Drosophila intestine

    Jerome Bohere, Buffy L Eldridge-Thomas, Golnar Kolahgar
    A subset of intestinal precursor cells is able to sense mechanical forces at cell–cell junctions to control the production of specialised cells.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Highly efficient generation of isogenic pluripotent stem cell models using prime editing

    Hanqin Li, Oriol Busquets ... Frank Soldner
    A highly efficient platform to engineer designer mutations in human stem cells using RNA-based delivery of prime editing components.
    1. Stem Cells and Regenerative Medicine

    Hepatic lipid overload potentiates biliary epithelial cell activation via E2Fs

    Ece Yildiz, Gaby El Alam ... Kristina Schoonjans
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration

    Camilo Riquelme-Guzmán, Stephanie L Tsai ... Tatiana Sandoval-Guzmán
    In vivo evaluation of mineralized skeleton in the regenerating axolotl limb reveals a significant osteoclast-driven resorption as an early event with long-lasting impact for tissue integration.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Airway basal cells show regionally distinct potential to undergo metaplastic differentiation

    Yizhuo Zhou, Ying Yang ... Wellington V Cardoso
    A combination of unbiased scRNA-sequencing and functional approaches in organoid cultures and injury-repair models in vivo reveals major heterogeneity in adult murine airway basal cells, which is established prenatally and conserved in humans.
    1. Stem Cells and Regenerative Medicine

    In vivo generation of bone marrow from embryonic stem cells in interspecies chimeras

    Bingqiang Wen, Guolun Wang ... Vladimir V Kalinichenko
    Blastocyst complementation of rat embryos with donor mouse embryonic stem cells was used to simultaneously produce multiple, donor-derived hematopoietic and stromal cells in the interspecies bone marrow that exhibited normal gene expression signatures, cell surface markers, and functional characteristics.

Senior editors

  1. Utpal Banerjee
    University of California, Los Angeles, United States
  2. Marianne E Bronner
    Marianne E Bronner
    California Institute of Technology, United States
  3. Edward Morrisey
    University of Pennsylvania, United States
  4. See more editors