Stem Cells and Regenerative Medicine

Latest articles

1. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals

   Amrita A Iyer, Ishwar Hosamani ... Andrew K Groves

   Cells of the mammalian cochlea can be reprogrammed to produce mechanosensory hair cells, but epigenetic changes in the cochlea make this process less efficient with age.
2. 1. Stem Cells and Regenerative Medicine

   High-resolution imaging of the osteogenic and angiogenic interface at the site of murine cranial bone defect repair via multiphoton microscopy

   Kevin Schilling, Yuankn Zhai ... Xinping Zhang

   High-resolution multiphoton microscopy reveals coupling of blood vessel subtype with expanding osteoblasts at the bone regeneration interface, further highlighting the heterogeneity of oxygen microenvironment and its impact on cellular energy metabolism of bone and vessel forming cells.
3. 1. Cell Biology
   2. Stem Cells and Regenerative Medicine

   Mettl3-mediated m⁶A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration

   Fu-Qing Jiang, Kun Liu ... Xu-Feng Qi

   Mettl3 post-transcriptionally reduces Fgf16 mRNA levels through an m⁶A-Ythdf2-dependen pathway, thereby controlling cardiomyocyte proliferation and heart regeneration.
4. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing

   Wenbo Liu, Xukun Lu ... Jianqiao Liu

   SRSF10 directly binds genes functioning in spermatogonia and regulates their alternative splicing, the defect of which can lead to progenitor expansion failure.
5. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Vinculin recruitment to α-catenin halts the differentiation and maturation of enterocyte progenitors to maintain homeostasis of the Drosophila intestine

   Jerome Bohere, Buffy L Eldridge-Thomas, Golnar Kolahgar

   A subset of intestinal precursor cells is able to sense mechanical forces at cell–cell junctions to control the production of specialised cells.
6. 1. Genetics and Genomics
   2. Stem Cells and Regenerative Medicine

   Highly efficient generation of isogenic pluripotent stem cell models using prime editing

   Hanqin Li, Oriol Busquets ... Frank Soldner

   A highly efficient platform to engineer designer mutations in human stem cells using RNA-based delivery of prime editing components.
7. 1. Stem Cells and Regenerative Medicine

   Hepatic lipid overload potentiates biliary epithelial cell activation via E2Fs

   Ece Yildiz, Gaby El Alam ... Kristina Schoonjans
8. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration

   Camilo Riquelme-Guzmán, Stephanie L Tsai ... Tatiana Sandoval-Guzmán

   In vivo evaluation of mineralized skeleton in the regenerating axolotl limb reveals a significant osteoclast-driven resorption as an early event with long-lasting impact for tissue integration.
9. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Airway basal cells show regionally distinct potential to undergo metaplastic differentiation

   Yizhuo Zhou, Ying Yang ... Wellington V Cardoso

   A combination of unbiased scRNA-sequencing and functional approaches in organoid cultures and injury-repair models in vivo reveals major heterogeneity in adult murine airway basal cells, which is established prenatally and conserved in humans.
10. 1. Stem Cells and Regenerative Medicine

    In vivo generation of bone marrow from embryonic stem cells in interspecies chimeras

    Bingqiang Wen, Guolun Wang ... Vladimir V Kalinichenko

    Blastocyst complementation of rat embryos with donor mouse embryonic stem cells was used to simultaneously produce multiple, donor-derived hematopoietic and stromal cells in the interspecies bone marrow that exhibited normal gene expression signatures, cell surface markers, and functional characteristics.