Stem Cells and Regenerative Medicine

Latest articles

1. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Generation of inner ear hair cells by direct lineage conversion of primary somatic cells

   Louise Menendez et al.

   Direct reprogramming of somatic cells to an inner ear sensory hair cell-like state provides an experimental platform to identify causes and treatments for hair cell loss and hearing deficits.
2. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Tgfβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration

   Deepak A Kaji et al.

   TGFß signaling regulates migration of tenogenic cells from Scx- and non-Scx lineages and is required for functional regeneration after neonatal tendon injury.
3. 1. Stem Cells and Regenerative Medicine

   Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model

   Hyunah Lee et al.

   Sequential introduction of transcription factors enables large-scale generation of induced motor neurons (iMNs) from human somatic cells, and transplantation of iMNs exhibit therapeutic effects in spinal cord injury model.
4. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Damage-responsive, maturity-silenced enhancers regulate multiple genes that direct regeneration in Drosophila

   Robin E Harris et al.

   The reduced ability of Drosophila imaginal discs to regenerate as they mature can be explained by the silencing of damage-responsive enhancers that regulate expression of genes required for regeneration.
5. 1. Neuroscience
   2. Stem Cells and Regenerative Medicine

   Hippocampal neural stem cells facilitate access from circulation via apical cytoplasmic processes

   Tamar Licht et al.

   Neural stem cells in the dentate gyrus have unique cytoplasmic processes that promote privileged access to circulating factors by a unique contact point with an endothelial cell.
6. 1. Stem Cells and Regenerative Medicine

   Tgfb3 collaborates with PP2A and notch signaling pathways to inhibit retina regeneration

   Mi-Sun Lee et al.

   Tgfb3 inhibits Muller glial cell reprogramming and drives Muller cell quiescence in the injured zebrafish retina, thereby inhibiting retina regeneration.
7. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Chromatin accessibility dynamics and single cell RNA-Seq reveal new regulators of regeneration in neural progenitors

   Anneke Dixie Kakebeen et al.

   Regenerating neural progenitors of the Xenopus tropicalis tail prioritize differentiation to motor neuron types earlier than proliferation, a decision partly regulated by the transcription factors Pbx3 and Meis1.
8. 1. Cell Biology
   2. Stem Cells and Regenerative Medicine

   Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish

   Mounir El Maï et al.

   Telomere shortening with age promotes a switch from p53-dependent apoptosis to senescence prompted by tissue damage that triggers conflicting mTOR/AKT signalling, lower OxPhos defences and ROS, mitochondria dysfunction and senescence.
9. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   R-spondin signalling is essential for the maintenance and differentiation of mouse nephron progenitors

   Valerie PI Vidal et al.

   In the developing kidney, secreted molecules of the R-spondin family control progenitor cell proliferation and nephron formation by permitting WNT/β-catenin signalling.
10. 1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Progenitors oppositely polarize WNT activators and inhibitors to orchestrate tissue development

    Irina Matos et al.

    Progenitors establish a single-cell length WNT morphogen gradient to transmit signals directionally and differentially to neighbors.