Stem Cells and Regenerative Medicine

Latest articles

1. 1. Neuroscience
   2. Stem Cells and Regenerative Medicine

   Base editing of Ptbp1 in neurons alleviates symptoms in a mouse model of Parkinson’s disease

   Desiree Böck, Maria Wilhelm ... Gerald Schwank

   Downregulation of PTBP1 in neurons, but not astrocytes, alleviates motor symptoms in a Parkinson’s disease mouse model by inducing dopaminergic marker expression in striatal neurons and increasing striatal dopamine levels.
2. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   A novel human pluripotent stem cell gene activation system identifies IGFBP2 as a mediator in the production of haematopoietic progenitors in vitro

   Paolo Petazzi, Telma Ventura ... Antonella Fidanza

   A novel tool is used to assess gene function in vitro by targeted endogenous transcriptional activation to unveil novel players in development and disease.
3. 1. Stem Cells and Regenerative Medicine

   Rejuvenating aged osteoprogenitors for bone repair

   Joshua Reeves, Pierre Tournier ... Shukry J Habib

   Short-term interventions, including intermittent fasting, boosting cellular energy, and promoting beneficial gut bacteria, rejuvenate osteoprogenitors in aged animals and, when combined with localized Wnt, restore youthful bone healing.
4. 1. Stem Cells and Regenerative Medicine

   Autologous P63+ lung progenitor cell transplantation in idiopathic pulmonary fibrosis: a phase 1 clinical trial

   Shiyu Zhang, Min Zhou ... Wei Zuo
5. 1. Genetics and Genomics
   2. Stem Cells and Regenerative Medicine

   A multiplexed, single-cell sequencing screen identifies compounds that increase neurogenic reprogramming of murine Muller glia

   Amy Tresenrider, Marcus Hooper ... Thomas A Reh

   An in vitro chemical screen with single-cell sequencing output leads to the identification of Metformin as an in vivo enhancer of Muller glia to neuron reprogramming in mice.
6. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   The Drosophila hematopoietic niche assembles through collective cell migration controlled by neighbor tissues and Slit-Robo signaling

   Kara A Nelson, Kari F Lenhart ... Stephen DiNardo
7. 1. Stem Cells and Regenerative Medicine

   Pharmacologically inducing regenerative cardiac cells by small molecule drugs

   Wei Zhou, Kezhang He ... Sheng Ding

   Induction of regenerative cardiac cells (RCCs) from human embryonic stem cell-derived cardiomyocytes and neonatal rat cardiomyocytes using a novel two-compound treatment enhances heart function following myocardial infarction and offers a promising avenue for cardiac regeneration through transcriptional and epigenetic reprogramming.
8. 1. Stem Cells and Regenerative Medicine

   Single-nucleus transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration

   Simon Perrin, Maria Ethel ... Céline Colnot

   A single-nucleus atlas of bone repair uncovers the trajectories of periosteal skeletal stem/progenitor cells in response to fracture and identifies injury-induced fibrogenic cells as intermediate osteochondroprogenitors and key paracrine regulators.
9. 1. Stem Cells and Regenerative Medicine

   Dynamic tracking of native precursors in adult mice

   Suying Liu, Sarah E Adams ... Peter Kurre

   A revised analytical framework grounded in the principle of binomial distribution captures the full clonality and dynamic shifts of hematopoiesis throughout ontogeny.
10. 1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Axon-specific microtubule regulation drives asymmetric regeneration of sensory neuron axons

    Ana C Costa, Blanca R Murillo ... Monica M Sousa