Stem Cells and Regenerative Medicine

Stem Cells and Regenerative Medicine

eLife publishes research on stem cell function, organogenesis, and tissue regeneration. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Generation of vascularized brain organoids to study neurovascular interactions

    Xin-Yao Sun et al.
    A vessel and brain fusion organoid model provides a platform for the study of interactions between neuronal and non-neuronal components during brain development and functioning.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Brain Organoids: Getting the right cells

    Bilal Cakir, In-Hyun Park
    Fusing brain organoids with blood vessel organoids leads to the incorporation of non-neural endothelial cells and microglia into the brain organoids.
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    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Robotic search for optimal cell culture in regenerative medicine

    Genki N Kanda et al.
    Robotic AI system automated discovery of optimum cell culture protocol, a most experience-dependent process in regenerative medicine.
    1. Stem Cells and Regenerative Medicine

    Cardiac differentiation of human pluripotent stem cells using defined extracellular matrix proteins reveals essential role of fibronectin

    Jianhua Zhang et al.
    Investigation of defined extracellular matrix proteins in differentiation of human pluripotent stem cells to cardiomyocytes reveals fibronectin, in addition to soluble factors, is required for cardiogenesis.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Repressing PTBP1 fails to convert reactive astrocytes to dopaminergic neurons in a 6-hydroxydopamine mouse model of Parkinson’s disease

    Weizhao Chen et al.
    Repressing astroglial PTBP1 by shRNA or antisense oligonucleotide fails to convert astrocyte to neuron including dopaminergic neuron in a 6-OHDA mouse model of PD.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Brain Repair: Gatekeeping astrocyte identity

    Alexis Cooper, Benedikt Berninger
    New findings cast doubt on whether suppressing the RNA-binding protein PTBP1 can force astrocytes to become dopaminergic neurons.
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    1. Stem Cells and Regenerative Medicine

    GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells

    Rafael Jesus Fernandez et al.
    Telomere dysfunction in iPSC-derived type II alveolar epithelial cells causes senescence and gene expression changes including Wnt-related changes that GSK3 inhibition can rescue, providing insight into pulmonary fibrosis pathogenesis.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Chondroitin sulfate proteoglycan 4,6 sulfation regulates sympathetic nerve regeneration after myocardial infarction

    Matthew R Blake et al.
    4,6-Sulfation of chondroitin sulfate proteoglycans prevents sympathetic nerve regeneration into the infarct after myocardial ischemia/reperfusion, and reducing this sulfation promotes nerve regeneration and decreases arrhythmia susceptibility.

Senior editors

  1. Utpal Banerjee
    University of California, Los Angeles, United States
  2. Marianne E Bronner
    Marianne E Bronner
    California Institute of Technology, United States
  3. Edward Morrisey
    University of Pennsylvania, United States
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