Stem Cells and Regenerative Medicine

Latest articles

1. 1. Stem Cells and Regenerative Medicine
   2. Developmental Biology

   Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids

   Jaydeep Sidhaye, Philipp Trepte ... Jürgen A Knoblich

   RNA-protein multiome approach helps to discover that the posttranscriptional regulation of the translational machinery is crucial for the fidelity of cortical development.
2. 1. Stem Cells and Regenerative Medicine

   Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs

   Ece Yildiz, Gaby El Alam ... Kristina Schoonjans

   Chronic fat overload triggers the conversion of quiescent biliary epithelial cells into proliferative progenitors through an E2F-dependent mechanism.
3. 1. Stem Cells and Regenerative Medicine

   Live imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation in vivo

   Dennis May, Sangwon Yun ... Valentina Greco

   Chromatin gradually rearranges during epidermal stem cell differentiation, while transcription of a differentiation-associated gene is extremely dynamic.
4. 1. Stem Cells and Regenerative Medicine
   2. Cancer Biology

   Mesenchymal stem cell suppresses the efficacy of CAR-T toward killing lymphoma cells by modulating the microenvironment through stanniocalcin-1

   Rui Zhang, Qingxi Liu ... Wenjian Ma

   The stanniocalcin-1-dependent immunosuppressive roles of mesenchymal stem cell on chimeric antigen receptor modified T cell therapy.
5. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Lineage-specific differences and regulatory networks governing human chondrocyte development

   Daniel Richard, Steven Pregizer ... April M Craft
6. 1. Cell Biology
   2. Stem Cells and Regenerative Medicine

   Nuclear m6A reader YTHDC1 promotes muscle stem cell activation/proliferation by regulating mRNA splicing and nuclear export

   Yulong Qiao, Qiang Sun ... Huating Wang
7. 1. Stem Cells and Regenerative Medicine

   Identification of phenotypically, functionally, and anatomically distinct stromal niche populations in human bone marrow based on single-cell RNA sequencing

   Hongzhe Li, Sandro Bräunig ... Stefan Scheding
8. 1. Stem Cells and Regenerative Medicine

   Inhibition of Type I PRMTs Reforms Muscle Stem Cell Identity Enhancing their Therapeutic Capacity

   Claudia Dominici, Oscar Villareal ... Stéphane Richard
9. 1. Stem Cells and Regenerative Medicine

   Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes

   Amanda R Dicks, Grigory I Maksaev ... Farshid Guilak

   Chondrocytes derived from induced pluripotent stem cells with the dysplasia-causing TRPV4 mutations, V620I and T89I mutation, were resistant to BMP4-induced hypertrophy, suggesting a mechanism underlying the effects of TRPV4 dysfunction on the severity of skeletal dysplasia.
10. 1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression

    Merrick D Pierson Smela, Christian C Kramme ... George M Church

    Making human stem cells express certain transcription factors can convert them into cells that are similar to ovarian granulosa cells, and perform several important functions of the ovary.