Stem Cells and Regenerative Medicine

Latest articles

1. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   YAP drives cutaneous squamous cell carcinoma formation and progression

   Zoé Vincent-Mistiaen et al.

   High levels of nuclear YAP are sufficient to drive squamous cell carincoma formation and frequently also drive progression to spindle cell carcinoma by promoting epithelial-to-mesenchymal transition after tissue damage.
2. 1. Neuroscience
   2. Stem Cells and Regenerative Medicine

   The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking

   Bo Li et al.

   The retromer complex serves as a bomb squad to retrieve and disarm the potentially harmful pool of Notch receptors in a timely manner and thereby safeguards against brain tumor formation.
3. 1. Neuroscience
   2. Stem Cells and Regenerative Medicine

   Piezo1 forms a slowly-inactivating mechanosensory channel in mouse embryonic stem cells

   Josefina Inés del Mármol et al.

   Piezo1 exhibits markedly different kinetic behavior in different cellular contexts.
4. 1. Cancer Biology
   2. Stem Cells and Regenerative Medicine

   HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties

   Ethan V Abel et al.

   HNF1A, a risk factor gene for pancreatic ductal adenocarcinoma, is critical to maintaining pancreatic cancer stem cell properties through regulating POU5F1 (OCT4) expression, providing a novel role for HNF1A in maintenance of the disease.
5. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Pdgfra marks a cellular lineage with distinct contributions to myofibroblasts in lung maturation and injury response

   Rongbo Li et al.

   Lineage tracing using a knockin Pdgfra-rtTA tool indicates distinct contributions of this cell lineage to myofibroblasts in normal development, fibrosis and bronchopulmonary dysplasia models.
6. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Differential expression of Lutheran/BCAM regulates biliary tissue remodeling in ductular reaction during liver regeneration

   Yasushi Miura et al.

   Lutheran is a novel marker for classification of bile duct remodeling in distinct liver injury, and an interesting functional molecule for investigating the nature of liver stem/progenitor cells during regeneration.
7. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Human axial progenitors generate trunk neural crest cells in vitro

   Thomas JR Frith et al.

   Pluripotent stem cell differentiation provides insight into how neural crest subtypes of distinct axial identity are patterned in human embryos.
8. 1. Cell Biology
   2. Stem Cells and Regenerative Medicine

   The role of Pitx2 and Pitx3 in muscle stem cells gives new insights into P38α MAP kinase and redox regulation of muscle regeneration

   Aurore Lhonore et al.
9. 1. Chromosomes and Gene Expression
   2. Stem Cells and Regenerative Medicine

   Decoupling the impact of microRNAs on translational repression versus RNA degradation in embryonic stem cells

   Jacob W Freimer et al.

   The deletion of Ddx6 results in the translational upregulation, but not transcript stabilization, of microRNA targets in embryonic stem cells while largely phenocopying the overall impact of global microRNA loss.
10. 1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters

    Ryo Nabeshima et al.

    Fam60a, a component of the Sin3a complex, is required for embryonic development and regulates methylation at a subset of gene promoters.