Stem Cells and Regenerative Medicine

Latest articles

1. 1. Neuroscience
   2. Stem Cells and Regenerative Medicine

   Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons

   Disi An et al.

   Stem cell-derived motor neurons with differential ALS vulnerability identified proteasome activity as a possible mechanism that explains their differential sensitivity.
2. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Epithelial geometry regulates spindle orientation and progenitor fate during formation of the mammalian epidermis

   Kimberly Box et al.

   Early in mammalian epidermal development, basal epidermal progenitor cells utilize packing and three-dimensional geometry, rather than cortical polarity cues, to inform division orientation and progenitor cell fate.
3. 1. Stem Cells and Regenerative Medicine

   Cell non-autonomous functions of S100a4 drive fibrotic tendon healing

   Jessica E Ackerman et al.

   Inhibition of S100a4 represents a novel anti-fibrotic target to improve tendon healing.
4. 1. Stem Cells and Regenerative Medicine

   Nuclear receptor NR4A is required for patterning at the ends of the planarian anterior-posterior axis

   Dayan J Li et al.

   NR4A is a broadly conserved transcription factor that is required for concordance of patterning information and anatomy at both ends of the planarian anterior-posterior axis.
5. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Stem cell topography splits growth and homeostatic functions in the fish gill

   Julian Stolper et al.

   The fish gill, an ever-growing organ with fast turnover rate, displays dedicated stem-cell populations for growth and homeostasis that are interchangeable upon external challenges.
6. 1. Chromosomes and Gene Expression
   2. Stem Cells and Regenerative Medicine

   MicroRNA-deficient mouse embryonic stem cells acquire a functional interferon response

   Jeroen Witteveldt et al.

   MiRNA-mediated suppression of MAVS expression in embryonic stem cells is necessary to inactivate the type I interferon response.
7. 1. Stem Cells and Regenerative Medicine

   Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons

   Joseph Herdy et al.

   An unbiased RNAseq based strategy to identify targetable pathways and a streamlined lentiviral system provide a state of the art advance on direct fibroblast to neuron conversion.
8. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction

   Mohsen Afshar Bakooshli et al.

   Human skeletal muscle progenitors and motor neurons self-organize in three-dimensional co-culture to form functional neuromuscular junctions that developmentally mature from the embryonic to the adult state.
9. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Myonuclear accretion is a determinant of exercise-induced remodeling in skeletal muscle

   Qingnian Goh et al.

   Fusion of muscle progenitors drives continuous myonuclear accretion during exercise and impacts various adaptations in skeletal muscle including response to injury and hypertrophy.
10. 1. Stem Cells and Regenerative Medicine

    Sox9+ messenger cells orchestrate large-scale skeletal regeneration in the mammalian rib

    Stephanie T Kuwahara et al.

    Large-scale skeletal regeneration requires Hh signaling in Sox9+ lineage cells to coordinate callus formation and bone repair.