Stem Cells and Regenerative Medicine

Latest articles

1. 1. Cancer Biology
   2. Stem Cells and Regenerative Medicine

   RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis

   Máté Nászai et al.

   Combined genetic experiments and cellular trafficking assays in Drosophila and mammalian models uncover a new role of RAS-like GTPases in EGFR signalling activation during tissue regeneration and tumourigenesis through regulation of EGFR internalisation.
2. 1. Cell Biology
   2. Stem Cells and Regenerative Medicine

   SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B

   Wei Fan et al.

   SIRT1, a cellular metabolic sensor, transcriptionally promotes sphingomyelin degradation in embryonic stem cells, which in turn modulates their membrane fluidity and neural differentiation.
3. 1. Cell Biology
   2. Stem Cells and Regenerative Medicine

   Wnt- and glutamate-receptors orchestrate stem cell dynamics and asymmetric cell division

   Sergi Junyent et al.

   Receptors for two distinct pathways are linked to choreograph the dynamic interaction of Wnt on the stem cell membrane, which leads to the control of asymmetric cell division.
4. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair

   Yulong Wei et al.

   Meniscal Gli1+ cells are mesenchymal progenitors that contribute to the development and injury repair of meniscus.
5. 1. Stem Cells and Regenerative Medicine

   HSPCs display within-family homogeneity in differentiation and proliferation despite population heterogeneity

   Tamar Tak et al.

   Hematopoietic stem and progenitor cells are heterogeneous on a population level, while cells derived from a common ancestor have similar division and differentiation patterns, indicating priming towards a certain differentiation/division fate.
6. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Onset of taste bud cell renewal starts at birth and coincides with a shift in SHH function

   Erin J Golden et al.

   Taste cell renewal begins at birth and is promoted by sonic hedgehog that alters the expression of regulators of cell migration and adhesion that may allow entry of new cells into buds.
7. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Non-canonical Hedgehog signaling regulates spinal cord and muscle regeneration in Xenopus laevis larvae

   Andrew M Hamilton et al.

   Unlike in early embryonic development, injured spinal cord and muscle in Xenopus laevis larvae recruit non-canonical Hedgehog signaling essential for their regeneration, while repressing Gli transcriptional activity.
8. 1. Computational and Systems Biology
   2. Stem Cells and Regenerative Medicine

   The biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function

   Zachary Clemens et al.

   Transcriptomic analysis using a novel information-based network entropy approach provides mechanistic insights into the ability of Klotho to successfully ameliorate age-related sarcopenia in old mice, but not oldest-old mice.
9. 1. Cell Biology
   2. Stem Cells and Regenerative Medicine

   The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation

   Emma Carley et al.

   Forces stemming from cell-matrix adhesions, but not cell-cell adhesions, are directly transmitted to the nuclear lamina to regulate epidermal cell fate.
10. 1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Generic injuries are sufficient to induce ectopic Wnt organizers in Hydra

    Jack F Cazet et al.

    Injuries activate the oral identity-specifying canonical Wnt signaling pathway in Hydra, which can trigger head regeneration in permissive tissue contexts created by the absence of pre-existing organizers.