Stem Cells and Regenerative Medicine

Latest articles

1. 1. Cell Biology
   2. Stem Cells and Regenerative Medicine

   Inducible and reversible inhibition of miRNA-mediated gene repression in vivo

   Gaspare La Rocca et al.

   A new genetically engineered mouse strain is described in which miRNA activity can be acutely and reversibly inhibited, showing that in a subset of adult tissues miRNA activity is dispensable under homeostatic conditions but becomes essential during tissue regeneration.
2. 1. Medicine
   2. Stem Cells and Regenerative Medicine

   Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19

   Courtney Tindle et al.

   An integrated stem cell-based disease modeling and computational approach demonstrates how proximal airway epithelium is critical for SARS-CoV-2 infectivity and distal alveolar cells are critical for simulating the host responses.
3. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Multiscale analysis reveals that diet-dependent midgut plasticity emerges from alterations in both stem cell niche coupling and enterocyte size

   Alessandro Bonfini et al.
4. 1. Stem Cells and Regenerative Medicine

   Thrombopoietin from hepatocytes promotes hematopoietic stem cell regeneration after myeloablation

   Longfei Gao et al.

   Systemic but not locally produced thrombopoietin promotes hematopoietic stem cell regeneration after myeloablation.
5. 1. Cell Biology
   2. Stem Cells and Regenerative Medicine

   The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling

   Jinrui Dong et al.

   IL6ST (gp130) binding proteins, such as HyperIL6, promote liver regrowth in a STAT3-indpependent manner through competitive inhibition of anti-regenerative IL11 signaling.
6. 1. Stem Cells and Regenerative Medicine

   Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial stem cells

   Diptiman Chanda et al.

   Lung stem cell niche aging is associated with altered bioenergetics, metabolic dysfunction, and senescence of mesenchymal stromal cells that restricts 3D organoid, or alveolosphere formation, potentially accounting for reduced regenerative capacity with aging.
7. 1. Neuroscience
   2. Stem Cells and Regenerative Medicine

   Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis

   Arantxa Cebrian-Silla et al.

   Adult neural stem cells differ in the types of neurons they generate according to their location and new territories and genes associated with dorsal and ventral neurogenic lineages in the adult mouse brain are revealed.
8. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells

   Suhong Sun et al.

   Adult cochlear supporting cells (SCs) are plastic and respond to ectopic Ikzf2 and Atoh1, and hair cell damage by up-regulating HC and down-regulating their endogenous SC genes.
9. 1. Cell Biology
   2. Stem Cells and Regenerative Medicine

   Filopodia powered by class X myosin promote fusion of mammalian myoblasts

   David W Hammers et al.
10. 1. Stem Cells and Regenerative Medicine

    TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells

    Anna Osnato et al.

    Identifying the pathways that support human naive-state pluripotent stem cells provides insights into the signalling-based regulation of human pluripotency and enables informed decisions to improve conditions for pluripotent cell culture.