Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval

  1. Maureen Ritchey  Is a corresponding author
  2. Maria E Montchal
  3. Andrew P Yonelinas
  4. Charan Ranganath
  1. University of California, Davis, United States

Abstract

The medial temporal lobes play an important role in episodic memory, but over time, hippocampal contributions to retrieval may be diminished. However, it is unclear whether such changes are related to the ability to retrieve contextual information, and whether they are common across all medial temporal regions. Here, we used functional neuroimaging to compare neural responses during immediate and delayed recognition. Results showed that recollection-related activity in the posterior hippocampus declined after a one-day delay. In contrast, activity was relatively stable in the anterior hippocampus and in neocortical areas. Multi-voxel pattern similarity analyses also revealed that anterior hippocampal patterns contained information about context during item recognition, and after a delay, context coding in this region was related to successful retention of context information. Together, these findings suggest that the anterior and posterior hippocampus have different contributions to memory over time and that neurobiological models of memory must account for these differences.

Article and author information

Author details

  1. Maureen Ritchey

    Center for Neuroscience, University of California, Davis, Davis, United States
    For correspondence
    meritchey@ucdavis.edu
    Competing interests
    The authors declare that no competing interests exist.
  2. Maria E Montchal

    Center for Neuroscience, University of California, Davis, Davis, United States
    Competing interests
    The authors declare that no competing interests exist.
  3. Andrew P Yonelinas

    Department of Psychology, University of California, Davis, Davis, United States
    Competing interests
    The authors declare that no competing interests exist.
  4. Charan Ranganath

    Center for Neuroscience, University of California, Davis, Davis, United States
    Competing interests
    The authors declare that no competing interests exist.

Reviewing Editor

  1. Howard Eichenbaum, Boston University, United States

Ethics

Human subjects: The study was approved by the Institutional Review Board at the University of California, Davis (protocol #238604). Written informed consent was obtained from each participant before the experiment, including consent to publish anonymized results.

Version history

  1. Received: October 10, 2014
  2. Accepted: January 9, 2015
  3. Accepted Manuscript published: January 13, 2015 (version 1)
  4. Version of Record published: February 6, 2015 (version 2)

Copyright

© 2015, Ritchey et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Maureen Ritchey
  2. Maria E Montchal
  3. Andrew P Yonelinas
  4. Charan Ranganath
(2015)
Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval
eLife 4:e05025.
https://doi.org/10.7554/eLife.05025

Share this article

https://doi.org/10.7554/eLife.05025

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