No turnover in lens lipids for the entire human lifespan

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Cite this article as: eLife 2015;4:e06003 doi: 10.7554/eLife.06003

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Abstract

Lipids are critical to cellular function and it is generally accepted that lipid turnover is rapid and dysregulation in turnover results in disease (Dawidowicz 1987, Phillips et al. 2009, Liu et al. 2013). Here we present an intriguing counter-example by demonstrating that in the center of the human ocular lens there is no lipid turnover in fiber cells during the entire human lifespan. This discovery, combined with prior demonstration of pronounced changes in the lens lipid composition over a lifetime (Hughes et al. 2012), suggests that some lipid classes break down in the body over several decades, whereas others are stable. Such substantial changes in lens cell membranes may play a role in the genesis of age-related eye disorders. Whether long-lived lipids are present in other tissues is not yet known, but this may prove to be important in understanding the development of age-related diseases.

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Author details

Jessica R Hughes

School of Medicine, University of Wollongong, Wollongong, Australia

For correspondence
jnealon@uow.edu.au

Competing interests
The authors declare that no competing interests exist.
Vladimir A Levchenko

The Australian Nuclear Science and Technology Organisation, Lucas Heights, Australia

Competing interests
The authors declare that no competing interests exist.
Stephen J Blanksby

Central Analytical Research Facility, Queensland University of Technology, Brisbane, Australia

Competing interests
The authors declare that no competing interests exist.
Todd W Mitchell

School of Medicine, University of Wollongong, Wollongong, Australia

Competing interests
The authors declare that no competing interests exist.
Alan Williams

The Australian Nuclear Science and Technology Organisation, Lucas Heights, Australia

Competing interests
The authors declare that no competing interests exist.
Roger J W Truscott

Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia

Competing interests
The authors declare that no competing interests exist.

Ethics

Human subjects: All work was approved by the human research ethics committees at the University of Sydney (#7292) and the University of Wollongong (HE 99/001). All human lenses from this study were donated to the Sydney Eye Bank.

Reviewing Editor

Jeremy Nathans, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, United States

Publication history

Received: December 10, 2014
Accepted: March 10, 2015
Accepted Manuscript published: March 11, 2015 (version 1)
Version of Record published: April 2, 2015 (version 2)

Copyright

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.