Projection neurons in Drosophila antennal lobes signal the acceleration of odor concentrations

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Abstract

Temporal experience of odor gradients is important in spatial orientation of animals. The fruit fly Drosophila melanogaster exhibits robust odor-guided behaviors in an odor gradient field. In order to investigate how early olfactory circuits process temporal variation of olfactory stimuli, we subjected flies to precisely defined odor concentration waveforms and examined spike patterns of olfactory sensory neurons (OSNs) and projection neurons (PNs). We found a significant temporal transformation between OSN and PN spike patterns, manifested by the PN output strongly signaling the OSN spike rate and its rate of change. A simple two-dimensional model admitting the OSN spike rate and its rate of change as inputs closely predicted the PN output. When cascaded with the rate-of-change encoding by OSNs, PNs primarily signal the acceleration and the rate-of-change of dynamic odor stimuli to higher brain centers, thereby enabling animals to reliably respond to the onsets of odor concentrations.

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Anmo J Kim

The Rockefeller University, New York, United States

Competing interests
The authors declare that no competing interests exist.
Aurel A Lazar

Department of Electrical Engineering, Columbia University, New York, United States

For correspondence
aurel@ee.columbia.edu

Competing interests
The authors declare that no competing interests exist.
Yevgeniy B Slutskiy

Department of Electrical Engineering, Columbia University, New York, United States

Competing interests
The authors declare that no competing interests exist.

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