Logics and properties of a genetic regulatory program that drives embryonic muscle development in an echinoderm

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Abstract

Evolutionary origin of muscle is a central question when discussing mesoderm evolution. Developmental mechanisms underlying somatic muscle development have mostly been studied in vertebrates and fly where multiple signals and hierarchic genetic regulatory cascades selectively specify myoblasts from a pool of naïve mesodermal progenitors. However, due to the increased organismic complexity and distant phylogenetic position of the two systems, a general mechanistic understanding of myogenesis is still lacking. Here, we propose a gene regulatory network (GRN) model that promotes myogenesis in the sea urchin embryo, an early branching deuterostome. A FGF signalling and four Forkhead transcription factors consist the central part of our model and appear to orchestrate the myogenic process. The topological properties of the network reveal dense gene interwiring and a multilevel transcriptional regulation of conserved and novel myogenic genes. Finally, the comparison of the myogenic network architecture among different animal groups highlights the evolutionary plasticity of developmental GRNs.

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Carmen Andrikou

Sars International Centre for Marine Molecular Biology, University of Bergen, Bergen, Norway

Competing interests
The authors declare that no competing interests exist.
Chih-Yu Pai

Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan

Competing interests
The authors declare that no competing interests exist.
Yi-Hsien Su

Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan

Competing interests
The authors declare that no competing interests exist.
Maria Ina Arnone

Cellular and Developmental Biology, Stazione Zoologica Anton Dohrn, Napoli, Italy

For correspondence
miarnone@szn.it

Competing interests
The authors declare that no competing interests exist.

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