1. Epidemiology and Global Health
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Childhood injury after a parental cancer diagnosis

  1. Ruoqing Chen  Is a corresponding author
  2. Amanda Regodón Wallin
  3. Arvid Sjölander
  4. Unnur Valdimarsdóttir
  5. Weimin Ye
  6. Henning Tiemeier
  7. Katja Fall
  8. Catarina Almqvist
  9. Kamila Czene
  10. Fang Fang
  1. Karolinska Institutet, Sweden
  2. Erasmus University, Netherlands
  3. Örebro University, Sweden
Research Article
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Cite this article as: eLife 2015;4:e08500 doi: 10.7554/eLife.08500

Abstract

A parental cancer diagnosis is psychologically straining for the whole family. We investigated whether a parental cancer diagnosis is associated with a higher-than-expected risk of injury among children by using a Swedish nationwide register-based cohort study. Compared to children without parental cancer, children with parental cancer had a higher rate of hospital contact for injury during the first year after parental cancer diagnosis (hazard ratio [HR]=1.27, 95% confidence interval [CI]=1.22-1.33), especially when the parent had a comorbid psychiatric disorder after cancer diagnosis (HR=1.41, 95% CI=1.08-1.85). The rate increment declined during the second and third year after parental cancer diagnosis (HR=1.10, 95% CI=1.07-1.14) and became null afterwards (HR=1.01, 95% CI=0.99-1.03). Children with parental cancer also had a higher rate of repeated injuries than the other children (HR=1.13, 95% CI= 1.12-1.15). Given the high rate of injury among children in the general population, our findings may have important public health implications.

Article and author information

Author details

  1. Ruoqing Chen

    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    For correspondence
    ruoqing.chen@ki.se
    Competing interests
    The authors declare that no competing interests exist.
  2. Amanda Regodón Wallin

    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Competing interests
    The authors declare that no competing interests exist.
  3. Arvid Sjölander

    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Competing interests
    The authors declare that no competing interests exist.
  4. Unnur Valdimarsdóttir

    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Competing interests
    The authors declare that no competing interests exist.
  5. Weimin Ye

    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Competing interests
    The authors declare that no competing interests exist.
  6. Henning Tiemeier

    Department of Epidemiology, Erasmus University Medical Center, Erasmus University, Rotterdam, Netherlands
    Competing interests
    The authors declare that no competing interests exist.
  7. Katja Fall

    Clinical Epidemiology and Biostatistics Unit, School of Health and Medical Sciences, Örebro University Hospital, Örebro University, Örebro, Sweden
    Competing interests
    The authors declare that no competing interests exist.
  8. Catarina Almqvist

    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Competing interests
    The authors declare that no competing interests exist.
  9. Kamila Czene

    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Competing interests
    The authors declare that no competing interests exist.
  10. Fang Fang

    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Competing interests
    The authors declare that no competing interests exist.

Ethics

Human subjects: The study was approved by the Central Ethical Review Board (Centrala etikpr�vningsn�mnden) in Stockholm, Sweden (Reg No. 2013/244-31/4). In accordance with their decision, we did not obtain informed consent from participants involved in the study. All individuals' information was anonymized and de-identified prior to analysis.

Reviewing Editor

  1. Eduardo Franco, McGill University, Canada

Publication history

  1. Received: May 4, 2015
  2. Accepted: October 27, 2015
  3. Accepted Manuscript published: October 31, 2015 (version 1)
  4. Version of Record published: February 9, 2016 (version 2)

Copyright

© 2015, Chen et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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