Innate immunity and training to subvert original antigenic sin by the humoral immune response
- The Ragon Institute of Mass General Brigham, MIT and Harvard, United States
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Figure 1
Selective innate immune support for expanding low-affinity B cells from the naïve B cell repertoire following immune challenge.
Recall of higher affinity B cells does not receive this support. Following infection or vaccination, memory B cells are rapidly recalled, which can underscore original antigenic sin (OAS) or primary addiction to previously imprinted antigen. By contrast, the concomitant de novo antibody response is triggered by immune complex formation, capture, and presentation to B cells, both initially by subcapsular sinus macrophages (SSM) and then later by follicular dendritic cells (FDCs) during the subsequent germinal center (GC) reaction; and in all cases is catalyzed by innate immune cells. We suggest that this organization could serve in the design of vaccines tasked with offsetting primary antigen addiction/OAS where the antibody response can become locked into recalling pre-existing memory states that then dominate the composition of antibodies in circulation.
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Innate immunity and training to subvert original antigenic sin by the humoral immune response
eLife 14:e106654.
https://doi.org/10.7554/eLife.106654
