Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows Spinocerebellar ataxia type 1 phenotypes
- Baylor College of Medicine, United States
- University of Texas Medical Branch, United States
- University of Minnesota, United States
Abstract
Previously we reported that ATXN1 oligomers are the primary drivers of toxicity in Spinocerebellar ataxia type 1 (SCA1; Lasagna-Reeves et al., 2015). Here we report that polyQ ATXN1 oligomers can propagate locally in vivo in mice predisposed to SCA1 following intracerebral oligomeric tissue inoculation. Our data also show that targeting these oligomers with passive immunotherapy leads to some improvement in motor coordination in SCA1 mice and to a modest increase in their life span. These findings provide evidence that oligomer propagation is regionally limited in SCA1 and that immunotherapy targeting extracellular oligomers can mildly modify disease phenotypes.
Article and author information
Author details
Reviewing Editor
- Bart De Strooper, VIB Center for the Biology of Disease, KU Leuven, Belgium
Ethics
Animal experimentation: This study was performed in strict accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health. All of the animals were handled according to approved institutional animal care and use committee (IACUC) protocols (#AN-1013) of Baylor College of Medicine
Version history
- Received: August 17, 2015
- Accepted: December 15, 2015
- Accepted Manuscript published: December 17, 2015 (version 1)
- Version of Record published: March 23, 2016 (version 2)
Copyright
© 2015, Lasagna-Reeves et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows Spinocerebellar ataxia type 1 phenotypes
eLife 4:e10891.
https://doi.org/10.7554/eLife.10891
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