(A, C, E, G) Relative density of 2n mono-nucleated, 2x×2n bi-nucleated, 4n mono-nucleated, 2x×4n bi-nucleated hepatocytes, respectively. (B, D, F, H) 3D visualization of the corresponding sub-populations of hepatocytes. The analysis was performed on 2559 hepatocytes (excluding boundary cells) from three adult mice. The CV-PV axis is determined by the coordinate χ, which describes the position of a point relative to the closest CV and PV. , where dcv and dpv are the distances to the closest CV and PV respectively, and D is the CV-PV distance. χ takes values between 0 and 100, where 0 and 100 represents a localization at the CV and PV surfaces, respectively.