(A) Representative behavioral seizures from the same vehicle (top)- and fadrozole (bottom)-treated rats as in Figure 1B plotted per sec. Each seizure behavior is indicated with a different color: staring (str, Racine 0, dark blue), chewing and head waving (C-HW, Racine 1–2, light blue), forelimb clonus (FLC, Racine 3 green), rearing (rear, Racine 4, yellow), falling (fall, Racine 5, orange), and tonic-clonic seizure (T-C, Racine 5, red). (B) EEG recording from the vehicle-treated rat shown in (A). (C) One early and one middle electrographic seizure are magnified to show their correspondence with mild limbic seizure behaviors using the same behavioral markers as in (A). (D, E) Cross-correlation of normalized hippocampal EEG amplitude (D) and β-low γ power (E) was stronger for mild limbic (Racine 0: staring (str), 1–2: chewing and head-waving (C-HW)) than convulsive seizures (Racine 3: forelimb clonus (FLC), 4: rearing, 5: falling) overall (**p<0.01 between each seizure behavior with post-hoc Newman-Keuls pairwise comparisons, vehicle: n=12, blue; fadrozole: n=9, orange). Fadrozole reduced the cross-correlation for some types of seizures (*p<0.05 between vehicle- and fadrozole-treated rats, unpaired t-tests). (F–H) Mean ± SEM percent time spent in seizures plotted in 5 min bins for all behaviors more severe than staring (Racine 1–5, F), mild limbic (Racine 1–2, G) or convulsive (Racine 3–5, H) seizures showing that behavioral seizure escalation evident in vehicle-treated rats was inhibited by fadrozole (*p<0.05 between vehicle- and fadrozole-treated rats, post-hoc unpaired t-tests). (I) Percentages of vehicle (blue, left)- and fadrozole (orange, right)-treated rats in behavioral SE are shown in 5 min bins. Fadrozole decreased the incidence of behavioral SE throughout 2 hrs (*p<0.05, ANOVA). (J) Percentages of vehicle- and fadrozole-treated rats in electrographic SE, which occurred only during the 2nd hr, are shown in 5 min bins. Fadrozole decreased the incidence of electrographic SE during the 2nd hr (*p<0.05, post-hoc unpaired t-tests).