Distributed task-specific processing of somatosensory feedback for voluntary motor control

  1. Mohsen Omrani
  2. Chantelle D Murnaghan
  3. J Andrew Pruszynski
  4. Stephen H Scott  Is a corresponding author
  1. Queen's Univertsity, Canada
  2. Queen's University, Canada
  3. Western University, Canada

Abstract

Corrective responses to limb disturbances are surprisingly complex, but the neural basis of these goal-directed responses is poorly understood. Here we show that somatosensory feedback is transmitted to many sensory and motor cortical regions within 25ms of a mechanical disturbance applied to the monkey's arm. When limb feedback was salient to an ongoing motor action (task engagement), neurons in parietal area 5 immediately (~25ms) increased their response to limb disturbances, whereas neurons in other regions did not alter their response until 15 to 40ms later. In contrast, initiation of a motor action elicited by a limb disturbance (target selection) altered neural responses in primary motor cortex ~65ms after the limb disturbance, and then in dorsal premotor cortex, with no effect in parietal regions until 150ms post-perturbation. Our findings highlight broad parietofrontal circuits provide the neural substrate for goal-directed corrections, an essential aspect of highly skilled motor behaviors.

Article and author information

Author details

  1. Mohsen Omrani

    Centre for Neuroscience Studies, Queen's Univertsity, Kingston, Canada
    Competing interests
    No competing interests declared.
  2. Chantelle D Murnaghan

    Centre for Neuroscience Studies, Queen's University, Kingston, Canada
    Competing interests
    No competing interests declared.
  3. J Andrew Pruszynski

    Physiology and Pharmacology, Psychology, Western University, London, Canada
    Competing interests
    No competing interests declared.
  4. Stephen H Scott

    Centre for Neuroscience Studies, Queen's University, Kingston, Canada
    For correspondence
    steve.scott@queensu.ca
    Competing interests
    Stephen H Scott, SHS is a Co-Founder and Chief Scientific Officer of BKIN Technologies that commercializes the robotic technology used in this study.

Reviewing Editor

  1. Rui M Costa, Fundação Champalimaud, Portugal

Ethics

Animal experimentation: The Queen's University Animal Care Committee approved all experimental procedures. (Protocol 1348)

Version history

  1. Received: November 20, 2015
  2. Accepted: April 13, 2016
  3. Accepted Manuscript published: April 14, 2016 (version 1)
  4. Version of Record published: May 19, 2016 (version 2)

Copyright

© 2016, Omrani et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Mohsen Omrani
  2. Chantelle D Murnaghan
  3. J Andrew Pruszynski
  4. Stephen H Scott
(2016)
Distributed task-specific processing of somatosensory feedback for voluntary motor control
eLife 5:e13141.
https://doi.org/10.7554/eLife.13141

Share this article

https://doi.org/10.7554/eLife.13141

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