Distributed task-specific processing of somatosensory feedback for voluntary motor control
Corrective responses to limb disturbances are surprisingly complex, but the neural basis of these goal-directed responses is poorly understood. Here we show that somatosensory feedback is transmitted to many sensory and motor cortical regions within 25ms of a mechanical disturbance applied to the monkey's arm. When limb feedback was salient to an ongoing motor action (task engagement), neurons in parietal area 5 immediately (~25ms) increased their response to limb disturbances, whereas neurons in other regions did not alter their response until 15 to 40ms later. In contrast, initiation of a motor action elicited by a limb disturbance (target selection) altered neural responses in primary motor cortex ~65ms after the limb disturbance, and then in dorsal premotor cortex, with no effect in parietal regions until 150ms post-perturbation. Our findings highlight broad parietofrontal circuits provide the neural substrate for goal-directed corrections, an essential aspect of highly skilled motor behaviors.
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Animal experimentation: The Queen's University Animal Care Committee approved all experimental procedures. (Protocol 1348)
- Rui M Costa, Fundação Champalimaud, Portugal
- Received: November 20, 2015
- Accepted: April 13, 2016
- Accepted Manuscript published: April 14, 2016 (version 1)
- Version of Record published: May 19, 2016 (version 2)
© 2016, Omrani et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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