Midbrain dopamine neurons compute inferred and cached value prediction errors in a common framework
- National Institutes of Health, United States
- University of Maryland School of Medicine, United States
- Johns Hopkins School of Medicine, United States
Figures
Figure 1
Rats infer the value of cues during sensory preconditioning.
Panels illustrate the task design and show the percentage of time spent in the food cup during presentation of the cues during each of the three phases of training. In the 'preconditioning' phase (A)…
Figure 2
VTA dopamine neurons exhibit firing to a reward-paired cue that is consistent with TD error signaling.
We recorded 632 neurons across all days of conditioning and the final reminder session. (A) Normalized responses (AUC) are displayed for each neuron, sorted by the classification algorithm applied …
Figure 3 with 3 supplements
VTA dopamine neurons exhibit firing to a pre-conditioned cue that is not consistent with TD error signaling.
We recorded 102 neurons during the probe test. AUC normalized neural responses were classified with a hierarchical clustering as in Figure 2 (A–D) in order to identify putative dopamine neurons (n = …
Figure 3—figure supplement 1
Neural responses from phasic and tonic wide-waveform neurons.
(A) raster plot of 18 trials of cue responses, resorted according to cue, for phasic responding wide waveform neuron. (B) baseline subtracted mean responses of panel (A) for cues B and D. (C) …
Figure 3—figure supplement 2
Neural responses from 39 neurons classified as tonically excited by cue B.
(A) baseline subtracted, mean responses of all neurons to cues B and D, +/- SEM (B) baseline subtracted, mean responses of all neurons to cues A and C, +/- SEM (C) histogram of differences in neural …
Figure 3—figure supplement 3
Neural responses from 11 neurons classified as tonically inhibited by cue B.
(A) baseline subtracted, mean responses of all neurons to cues B and D, +/- SEM (B) baseline subtracted, mean responses of all neurons to cues A and C, +/- SEM (C) histogram of differences in neural …
