An inhibitory corticostriatal pathway
- University of Texas at San Antonio, United States
Figures
Figure 1
Morphological characteristics, axonal projections and electrical properties of long-range CS-SOM neurons in the mouse auditory cortex.
(a) Schematic depicting injection site using the SOM-Cre-tdTomato transgenic mouse line to identify CS-SOM neurons and their projections to the dorsal striatum. Bottom, auditory cortex: AAV.GFP.Flex …
Figure 2
Photostimulation of auditory CS-SOM projections elicits direct inhibition and modulates action potentials in striatal SPNs.
(a) Schematic depicting injection site using the SOM-Cre transgenic mouse line to transfect CS-SOM projections to the dorsal striatum with ChR2. Bottom, auditory cortex: AAV.ChR2.flex injection …
Figure 3
Auditory CS-SOM neurons innervate both dSPNs and iSPNs.
(a) Experimental paradigm for photostimulating ChR2-positive CS-SOM projections while recording from genetically labeled dSPNs and iSPNs. (b) Left, epifluorescence image of dSPNs expressing D1-tdToma…
Figure 4
Photostimulation of motor CS-SOM projections elicits direct inhibition of striatal SPNs.
(a) Schematic depicting injection site using the SOM-Cre transgenic mouse line to transfect CS-SOM projections to the dorsal striatum with ChR2. Top, motor cortex: AAV.ChR2.flex injection site. …
Figure 5
Summary diagram: CS-SOM neurons directly inhibit striatal SPNs.
Auditory and motor CS-SOM projections modulate the activity of striatal SPNs by direct inhibition. Green lines: excitatory inputs from intratelencephalic (IT-type) and projecting-type (PT-type) …
