1. Biochemistry and Chemical Biology

How open science helps researchers succeed

  1. Erin C McKiernan  Is a corresponding author
  2. Philip E Bourne
  3. C Titus Brown
  4. Stuart Buck
  5. Amye Kenall
  6. Jennifer Lin
  7. Damon McDougall
  8. Brian A Nosek
  9. Karthik Ram
  10. Courtney K Soderberg
  11. Jeffrey R Spies
  12. Kaitlin Thaney
  13. Andrew Updegrove
  14. Kara H Woo
  15. Tal Yarkoni
  1. National Autonomous University of Mexico, Mexico
  2. National Institutes of Health, United States
  3. University of California, Davis, United States
  4. Laura and John Arnold Foundation, United States
  5. BioMed Central, United Kingdom
  6. CrossRef, United Kingdom
  7. University of Texas at Austin, United States
  8. Center for Open Science, United States
  9. University of California, Berkeley, United States
  10. Mozilla Foundation, United States
  11. Gesmer Updegrove LLP, United States
  12. Washington State University, United States
https://doi.org/10.7554/eLife.16800
Share this article
Cite this article
  1. Erin C McKiernan
  2. Philip E Bourne
  3. C Titus Brown
  4. Stuart Buck
  5. Amye Kenall
  6. Jennifer Lin
  7. Damon McDougall
  8. Brian A Nosek
  9. Karthik Ram
  10. Courtney K Soderberg
  11. Jeffrey R Spies
  12. Kaitlin Thaney
  13. Andrew Updegrove
  14. Kara H Woo
  15. Tal Yarkoni
(2016)
How open science helps researchers succeed
eLife 5:e16800.
https://doi.org/10.7554/eLife.16800
  2. Download BibTeX
  3. Download .RIS

Abstract

Open access, open data, open source, and other open scholarship practices are growing in popularity and necessity. However, widespread adoption of these practices has not yet been achieved. One reason is that researchers are uncertain about how sharing their work will affect their careers. We review literature demonstrating that open research is associated with increases in citations, media attention, potential collaborators, job opportunities, and funding opportunities. These findings are evidence that open research practices bring significant benefits to researchers relative to more traditional closed practices.

Article and author information

Author details

  1. Erin C McKiernan

    Department of Physics, National Autonomous University of Mexico, Mexico City, Mexico
    For correspondence
    emckiernan@ciencias.unam.mx
    Competing interests
    Erin C McKiernan, Founder of the 'Why Open Research?' project, an open research advocacy and educational site funded by the Shuttleworth Foundation. She is also a figshare and PeerJ Preprints advisor, Center for Open Science ambassador, and OpenCon organizing committee member - all volunteer positions.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-9430-5221

  2. Philip E Bourne

    Office of the Director, National Institutes of Health, Bethesda, United States
    Competing interests
    No competing interests declared.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-7618-7292

  3. C Titus Brown

    Population Health and Reproduction, University of California, Davis, Davis, United States
    Competing interests
    No competing interests declared.

  4. Stuart Buck

    Laura and John Arnold Foundation, Houston, United States
    Competing interests
    No competing interests declared.

  5. Amye Kenall

    BioMed Central, London, United Kingdom
    Competing interests
    Amye Kenall, Works at the open access publisher BioMed Central, a part of the larger SpringerNature company, where she leads initiatives around open data and research and oversees a portfolio of journals in the health sciences.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-3030-8001

  6. Jennifer Lin

    CrossRef, Oxford, United Kingdom
    Competing interests
    Jennifer Lin, Works for CrossRef and is involved in building infrastructure that supports open science research: Principles for Open Scholarly Research, open data initiatives, and open scholarly metadata.

  7. Damon McDougall

    Institute for Computational Engineering and Sciences, University of Texas at Austin, Austin, United States
    Competing interests
    No competing interests declared.

  8. Brian A Nosek

    Center for Open Science, Charlottesville, United States
    Competing interests
    Brian A Nosek, Employed by the non-profit Center for Open Science, which runs the Open Science Framework, and includes in its mission increasing openness.

  9. Karthik Ram

    Berkeley Institute for Data Science, University of California, Berkeley, Berkeley, United States
    Competing interests
    No competing interests declared.

  10. Courtney K Soderberg

    Center for Open Science, Charlottesville, United States
    Competing interests
    Courtney K Soderberg, Employed by the non-profit Center for Open Science, which runs the Open Science Framework, and includes in its mission increasing openness.

  11. Jeffrey R Spies

    Center for Open Science, Charlottesville, United States
    Competing interests
    Jeffrey R Spies, Employed by the non-profit Center for Open Science, which runs the Open Science Framework, and includes in its mission increasing openness.

  12. Kaitlin Thaney

    Mozilla Science Lab, Mozilla Foundation, New York, United States
    Competing interests
    Kaitlin Thaney, Employed by the Mozilla Foundation, where she leads the organization's open science program - the Mozilla Science Lab. The Science Lab supports fellowships, training and prototyping, including work on open research badges.

  13. Andrew Updegrove

    Gesmer Updegrove LLP, Boston, United States
    Competing interests
    No competing interests declared.

  14. Kara H Woo

    Center for Environmental Research, Education, and Outreach, Washington State University, Pullman, United States
    Competing interests
    No competing interests declared.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-5125-4188

  15. Tal Yarkoni

    Department of Psychology, University of Texas at Austin, Austin, United States
    Competing interests
    No competing interests declared.

Reviewing Editor

  1. Peter Rodgers, eLife, United Kingdom

Publication history

  1. Received: April 8, 2016
  2. Accepted: July 4, 2016
  3. Accepted Manuscript published: July 7, 2016 (version 1)
  4. Version of Record published: July 29, 2016 (version 2)

Copyright

© 2016, McKiernan et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

Metrics

  • 33,245
    Page views
  • 5,184
    Downloads
  • 353
    Citations

Article citation count generated by polling the highest count across the following sources: Scopus, Crossref, PubMed Central.

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Open citations (links to open the citations from this article in various online reference manager services)

Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)

  1. Erin C McKiernan
  2. Philip E Bourne
  3. C Titus Brown
  4. Stuart Buck
  5. Amye Kenall
  6. Jennifer Lin
  7. Damon McDougall
  8. Brian A Nosek
  9. Karthik Ram
  10. Courtney K Soderberg
  11. Jeffrey R Spies
  12. Kaitlin Thaney
  13. Andrew Updegrove
  14. Kara H Woo
  15. Tal Yarkoni
(2016)
How open science helps researchers succeed
eLife 5:e16800.
https://doi.org/10.7554/eLife.16800

Categories and tags

    1. Part of Collection

    Research Culture: A Selection of Articles

    Edited by Julia Deathridge
  2. Further reading

Further reading

  1. Research Culture: A Selection of Articles

    Edited by Julia Deathridge
    Collection

    Research culture needs to be improved for the benefit of science and scientists.

  2. In the open: Listen to Erin McKiernan talk about open science

    Podcast

    Researchers can benefit from making their research findings freely available online.

    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis

    Juan J Apiz Saab, Lindsey N Dzierozynski ... Alexander Muir
    Research Advance

    Nutrient stress in the tumor microenvironment requires cancer cells to adopt adaptive metabolic programs for survival and proliferation. Therefore, knowledge of microenvironmental nutrient levels and how cancer cells cope with such nutrition is critical to understand the metabolism underpinning cancer cell biology. Previously, we performed quantitative metabolomics of the interstitial fluid (the local perfusate) of murine pancreatic ductal adenocarcinoma (PDAC) tumors to comprehensively characterize nutrient availability in the microenvironment of these tumors (M. R. Sullivan, Danai, et al., 2019). Here, we develop Tumor Interstitial Fluid Medium (TIFM), a cell culture medium that contains nutrient levels representative of the PDAC microenvironment, enabling us to study PDAC metabolism ex vivo under physiological nutrient conditions. We show that PDAC cells cultured in TIFM adopt a cellular state closer to that of PDAC cells present in tumors compared to standard culture models. Further, using the TIFM model, we found arginine biosynthesis is active in PDAC and allows PDAC cells to maintain levels of this amino acid despite microenvironmental arginine depletion. We also show that myeloid derived arginase activity is largely responsible for the low levels of arginine in PDAC tumors. Altogether, these data indicate that nutrient availability in tumors is an important determinant of cancer cell metabolism and behavior, and cell culture models that incorporate physiological nutrient availability have improved fidelity to in vivo systems and enable the discovery of novel cancer metabolic phenotypes.