Hippocampal neurogenesis enhancers promote forgetting of remote fear memory after hippocampal reactivation by retrieval
- Tokyo University of Agriculture, Japan
- Japan Science and Technology Agency, Japan
- The Hospital for Sick Children, Canada
Figures
Figure 1
Memantine (MEM) treatment enhanced forgetting of contextual fear memory through the increase in adult hippocampal neurogenesis.
(A) MEM treatment enhanced forgetting of contextual fear memory in a manner dependent on the number of MEM treatments. [VEH = vehicle-treated group, n = 10; MEM (1), n = 10; MEM (4), n = 10]. (B) …
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Figure 1—source data 1
Summary of statistical analyses with F values.
The asterisks indicate a significant difference.
- https://doi.org/10.7554/eLife.17464.003
Figure 2
Memantine (MEM) treatment enhanced forgetting of hippocampus-dependent fear memory.
(A) MEM treatment enhanced forgetting of hippocampus-dependent inhibitory avoidance memory [vehicle treated group (VEH), n = 11; MEM group, n = 10]. (B) MEM-treated mice showed normal …
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Figure 2—source data 1
Summary of statistical analyses with F values.
The asterisks indicate a significant difference.
- https://doi.org/10.7554/eLife.17464.005
Figure 3
Enhancement of adult hippocampal neurogenesis after long-period recall enhanced forgetting of remote fear memory.
(A) Memantine (MEM) treatment enhanced forgetting of remote fear memory after 10 min re-exposure (3 min vehicle treatment group (VEH), n = 10; 3 min MEM-treated group, n = 10; 10 min VEH, n = 12; 10 …
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Figure 3—source data 1
Summary of statistical analyses with F values.
The asterisks indicate a significant difference.
- https://doi.org/10.7554/eLife.17464.007
Figure 4 with 1 supplement
Inhibition of protein synthesis in the hippocampus (HP) blocked reconsolidation of remote fear memory.
(A) Three min re-exposure to the context 24 hr after training [vehicle-treated group (VEH), n = 10; anisomycin (ANI), n = 15]. (B) Three min re-exposure to the context four weeks after training …
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Figure 4—source data 1
Summary of statistical analyses with F values.
The asterisks indicate a significant difference.
- https://doi.org/10.7554/eLife.17464.009
Figure 4—figure supplement 1
The cannula tip placement in the hippocampus.
(A–C) The cannula tip placement form mice infused with each drug as illustrated in Figure 4A (A), Figure 4B (B), and Figure 4C (C). Schematic drawings of coronal sections from all micro-infused …
Figure 5 with 1 supplement
Long-time retrieval of remote fear memory reactivated the hippocampus (HP).
(A) Representative immunohistochemical staining of the anterior cingulate cortex (ACC) and CA1 c-fos-positive cells from the indicated group. Scale bars = 100 μm. Two groups were trained with a foot …
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Figure 5—source data 1
Summary of statistical analyses with F values.
The asterisks indicate a significant difference.
- https://doi.org/10.7554/eLife.17464.012
Figure 5—figure supplement 1
The cannula tip placement in the hippocampus.
The cannula tip placement form mice infused with each drug as illustrated in Figure 5C. Schematic drawings of coronal sections from all micro-infused animals (hippocampus, 1.94 mm posterior to the …
