Interneuronal mechanisms of hippocampal theta oscillation in a full-scale model of the rodent CA1 circuit
- Boston University, United States
- Stanford University, United States
- University of California, Irvine, United States
Abstract
The hippocampal theta rhythm plays important roles in information processing; however, the mechanisms of its generation are not well understood. We developed a data-driven, supercomputer-based, full-scale (1:1) model of the rodent CA1 area and studied its interneurons during theta oscillations. Theta rhythm with phase-locked gamma oscillations and phase-preferential discharges of distinct interneuronal types spontaneously emerged from the isolated CA1 circuit without rhythmic inputs. Perturbation experiments identified parvalbumin-expressing interneurons and neurogliaform cells, as well as interneuronal diversity itself, as important factors in theta generation. These simulations reveal new insights into the spatiotemporal organization of the CA1 circuit during theta oscillations.
Data availability
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Simulation results from full scale and rationally reduced network models of the isolated hippocampal CA1 subfield in ratPublicly available at the Open Science Framework.
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Hippocampal CA1 network in parallel NEURON with spontaneous theta, gamma: full scale & network clampPublicly available at SenseLab (accession no: 187604).
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Firing pattern of O-LM cells in mouse hippocampal CA1.Publicly available at the Open Science Framework.
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Intracellular, in vitro somatic membrane potential recordings from whole cell patch clamped rodent hippocampal CA1 neurons.Publicly available at the Open Science Framework.
Article and author information
Author details
Marianne J Bezaire
Funding
National Institutes of Health (NS35915)
- Ivan Soltesz
National Science Foundation (IOS-1310378)
- Ivan Soltesz
National Institutes of Health (F32NS090753)
- Marianne J Bezaire
National Science Foundation (DGE-0808392)
- Marianne J Bezaire
NSF XSEDE Allocations (TG-IBN140007,TG-IBN130022,TG-IBN100011)
- Marianne J Bezaire
- Ivan Raikov
- Ivan Soltesz
National Institutes of Health (NS090583)
- Ivan Soltesz
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Reviewing Editor
- Frances K Skinner, University Health Network, Canada
Version history
- Received: June 12, 2016
- Accepted: December 15, 2016
- Accepted Manuscript published: December 23, 2016 (version 1)
- Version of Record published: February 16, 2017 (version 2)
Copyright
© 2016, Bezaire et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Interneuronal mechanisms of hippocampal theta oscillation in a full-scale model of the rodent CA1 circuit
eLife 5:e18566.
https://doi.org/10.7554/eLife.18566
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