Interneuronal mechanisms of hippocampal theta oscillation in a full-scale model of the rodent CA1 circuit

Abstract
Data availability
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Abstract

The hippocampal theta rhythm plays important roles in information processing; however, the mechanisms of its generation are not well understood. We developed a data-driven, supercomputer-based, full-scale (1:1) model of the rodent CA1 area and studied its interneurons during theta oscillations. Theta rhythm with phase-locked gamma oscillations and phase-preferential discharges of distinct interneuronal types spontaneously emerged from the isolated CA1 circuit without rhythmic inputs. Perturbation experiments identified parvalbumin-expressing interneurons and neurogliaform cells, as well as interneuronal diversity itself, as important factors in theta generation. These simulations reveal new insights into the spatiotemporal organization of the CA1 circuit during theta oscillations.

Data availability

The following data sets were generated

1. Bezaire MJ
2. Raikov I
3. Burk K
4. Vyas D
5. Soltesz I
(2015) Simulation results from full scale and rationally reduced network models of the isolated hippocampal CA1 subfield in rat
Publicly available at the Open Science Framework.

http://dx.doi.org/10.17605/OSF.IO/V4CEH
1. Bezaire MJ
2. Raikov I
(2016) Hippocampal CA1 network in parallel NEURON with spontaneous theta, gamma: full scale & network clamp
Publicly available at SenseLab (accession no: 187604).

https://senselab.med.yale.edu/ModelDB/showmodel.cshtml?model=187604

The following previously published data sets were used

1. Quattrocolo G
2. Maccaferri G
(2013) Firing pattern of O-LM cells in mouse hippocampal CA1.
Publicly available at the Open Science Framework.

http://dx.doi.org/10.17605/OSF.IO/RA8MW
(2016) Intracellular, in vitro somatic membrane potential recordings from whole cell patch clamped rodent hippocampal CA1 neurons.
Publicly available at the Open Science Framework.

http://dx.doi.org/10.17605/OSF.IO/M5EDM

Article and author information

Author details

Marianne J Bezaire

Department of Psychological and Brain Sciences, Boston University, Boston, United States

For correspondence
marianne.bezaire@gmail.com

Competing interests
The authors declare that no competing interests exist.

"This ORCID iD identifies the author of this article:" 0000-0001-6040-3520
Ivan Raikov

Department of Neurosurgery, Stanford University, Stanford, United States

Competing interests
The authors declare that no competing interests exist.

"This ORCID iD identifies the author of this article:" 0000-0002-8224-8549
Kelly Burk

Anatomy & Neurobiology, University of California, Irvine, Irvine, United States

Competing interests
The authors declare that no competing interests exist.
Dhrumil Vyas

Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, United States

Competing interests
The authors declare that no competing interests exist.
Ivan Soltesz

Department of Neurosurgery, Stanford University, Stanford, United States

Competing interests
The authors declare that no competing interests exist.

Funding

National Institutes of Health (NS35915)

Ivan Soltesz

National Science Foundation (IOS-1310378)

Ivan Soltesz

National Institutes of Health (F32NS090753)

Marianne J Bezaire

National Science Foundation (DGE-0808392)

Marianne J Bezaire

NSF XSEDE Allocations (TG-IBN140007,TG-IBN130022,TG-IBN100011)

Marianne J Bezaire
Ivan Raikov
Ivan Soltesz

National Institutes of Health (NS090583)

Ivan Soltesz

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Copyright

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.