Replication Study: BET bromodomain inhibition as a therapeutic strategy to target c-Myc
- Northwestern University, United States
Figures
Figure 1
MYC expression in JQ1-treated MM.1S-luc cells.
MM.1S-luc cells were treated with 500 nM (+)-JQ1, 500 nM (−)-JQ1, or an equivalent volume of DMSO. Total RNA was isolated at 0 hr, 1 hr, and 8 hr after treatment and qRT-PCR analysis was performed …
Figure 2
Overall survival in JQ1-treated MM.1S-luc orthotopic xenograft model.
Kaplan-Meier plot of overall survival during the pre-specified study period of 36 days. Female SCID-beige mice with established MM.1S-luc orthotopic xenografts were randomized to daily IP injections …
Figure 3 with 1 supplement
Tumor burden in JQ1-treated MM.1S-luc orthotopic xenograft model.
Female SCID-beige mice were orthotopically xenografted after intravenous injection with MM.1S-luc cells. Following detection of established disease (diffusely engrafted in the skeleton with an …
Figure 3—figure supplement 1
Individual tumor xenografts.
This is the same experiment as in Figure 3, but with the bioluminescence data plotted on a continuous scale (A) or natural log transformed scale (B) for each animal rather than averages. Female …
Figure 4
