Functional double dissociation within the entorhinal cortex for visual scene-dependent choice behavior
Abstract
How visual scene memory is processed differentially by the upstream structures of the hippocampus is largely unknown. We sought to dissociate functionally the lateral and medial subdivisions of the entorhinal cortex (LEC and MEC, respectively) in visual scene-dependent tasks by temporarily inactivating the LEC and MEC in the same rat. When the rat made spatial choices in a T-maze using visual scenes displayed on LCD screens, the inactivation of the MEC but not the LEC produced severe deficits in performance. However, when the task required the animal to push a jar or to dig in the sand in the jar using the same scene stimuli, the LEC but not the MEC became important. Our findings suggest that the entorhinal cortex is critical for scene-dependent mnemonic behavior, and the response modality may interact with sensory modality to determine the involvement of the LEC and MEC in scene-based memory tasks.
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Author details
Funding
National Research Foundation of Korea (2015M3C7A1031969)
- Inah Lee
National Research Foundation of Korea (2013R1A1A2062882)
- Inah Lee
National Research Foundation of Korea (2016R1A2B4008692)
- Inah Lee
National Research Foundation of Korea (2014051826)
- Inah Lee
National Research Foundation of Korea (BK21 plus program)
- Inah Lee
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Animal experimentation: This study was performed in strict accordance with the guidelines of the Institutional Animal Care and Use Committee of the Seoul National University. All protocols (SNU-120925-1-7) were in compliance with the Institutional Animal Care and Use Committee of the Seoul National University.
Reviewing Editor
- Neil Burgess, University College London, United Kingdom
Version history
- Received: September 14, 2016
- Accepted: February 6, 2017
- Accepted Manuscript published: February 7, 2017 (version 1)
- Version of Record published: February 14, 2017 (version 2)
- Version of Record updated: April 24, 2017 (version 3)
- Version of Record updated: April 24, 2017 (version 4)
- Version of Record updated: May 11, 2017 (version 5)
Copyright
© 2017, Yoo & Lee
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Further reading
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