Functional double dissociation within the entorhinal cortex for visual scene-dependent choice behavior

  1. Seung-Woo Yoo
  2. Inah Lee  Is a corresponding author
  1. Seoul National University, Republic of Korea

Abstract

How visual scene memory is processed differentially by the upstream structures of the hippocampus is largely unknown. We sought to dissociate functionally the lateral and medial subdivisions of the entorhinal cortex (LEC and MEC, respectively) in visual scene-dependent tasks by temporarily inactivating the LEC and MEC in the same rat. When the rat made spatial choices in a T-maze using visual scenes displayed on LCD screens, the inactivation of the MEC but not the LEC produced severe deficits in performance. However, when the task required the animal to push a jar or to dig in the sand in the jar using the same scene stimuli, the LEC but not the MEC became important. Our findings suggest that the entorhinal cortex is critical for scene-dependent mnemonic behavior, and the response modality may interact with sensory modality to determine the involvement of the LEC and MEC in scene-based memory tasks.

Article and author information

Author details

  1. Seung-Woo Yoo

    Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Republic of Korea
    Competing interests
    The authors declare that no competing interests exist.
  2. Inah Lee

    Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Republic of Korea
    For correspondence
    lee.inah@gmail.com
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-3760-4257

Funding

National Research Foundation of Korea (2015M3C7A1031969)

  • Inah Lee

National Research Foundation of Korea (2013R1A1A2062882)

  • Inah Lee

National Research Foundation of Korea (2016R1A2B4008692)

  • Inah Lee

National Research Foundation of Korea (2014051826)

  • Inah Lee

National Research Foundation of Korea (BK21 plus program)

  • Inah Lee

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Reviewing Editor

  1. Neil Burgess, University College London, United Kingdom

Ethics

Animal experimentation: This study was performed in strict accordance with the guidelines of the Institutional Animal Care and Use Committee of the Seoul National University. All protocols (SNU-120925-1-7) were in compliance with the Institutional Animal Care and Use Committee of the Seoul National University.

Version history

  1. Received: September 14, 2016
  2. Accepted: February 6, 2017
  3. Accepted Manuscript published: February 7, 2017 (version 1)
  4. Version of Record published: February 14, 2017 (version 2)
  5. Version of Record updated: April 24, 2017 (version 3)
  6. Version of Record updated: April 24, 2017 (version 4)
  7. Version of Record updated: May 11, 2017 (version 5)

Copyright

© 2017, Yoo & Lee

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

Metrics

  • 2,514
    views
  • 456
    downloads
  • 10
    citations

Views, downloads and citations are aggregated across all versions of this paper published by eLife.

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Open citations (links to open the citations from this article in various online reference manager services)

Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)

  1. Seung-Woo Yoo
  2. Inah Lee
(2017)
Functional double dissociation within the entorhinal cortex for visual scene-dependent choice behavior
eLife 6:e21543.
https://doi.org/10.7554/eLife.21543

Share this article

https://doi.org/10.7554/eLife.21543

Further reading

    1. Neuroscience
    Katharina Eichler, Stefanie Hampel ... Andrew M Seeds
    Research Advance

    Mechanosensory neurons located across the body surface respond to tactile stimuli and elicit diverse behavioral responses, from relatively simple stimulus location-aimed movements to complex movement sequences. How mechanosensory neurons and their postsynaptic circuits influence such diverse behaviors remains unclear. We previously discovered that Drosophila perform a body location-prioritized grooming sequence when mechanosensory neurons at different locations on the head and body are simultaneously stimulated by dust (Hampel et al., 2017; Seeds et al., 2014). Here, we identify nearly all mechanosensory neurons on the Drosophila head that individually elicit aimed grooming of specific head locations, while collectively eliciting a whole head grooming sequence. Different tracing methods were used to reconstruct the projections of these neurons from different locations on the head to their distinct arborizations in the brain. This provides the first synaptic resolution somatotopic map of a head, and defines the parallel-projecting mechanosensory pathways that elicit head grooming.