1. Neuroscience

Functional double dissociation within the entorhinal cortex for visual scene-dependent choice behavior

  1. Seung-Woo Yoo
  2. Inah Lee  Is a corresponding author
  1. Seoul National University, Republic of Korea
https://doi.org/10.7554/eLife.21543
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  1. Seung-Woo Yoo
  2. Inah Lee
(2017)
Functional double dissociation within the entorhinal cortex for visual scene-dependent choice behavior
eLife 6:e21543.
https://doi.org/10.7554/eLife.21543
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Abstract

How visual scene memory is processed differentially by the upstream structures of the hippocampus is largely unknown. We sought to dissociate functionally the lateral and medial subdivisions of the entorhinal cortex (LEC and MEC, respectively) in visual scene-dependent tasks by temporarily inactivating the LEC and MEC in the same rat. When the rat made spatial choices in a T-maze using visual scenes displayed on LCD screens, the inactivation of the MEC but not the LEC produced severe deficits in performance. However, when the task required the animal to push a jar or to dig in the sand in the jar using the same scene stimuli, the LEC but not the MEC became important. Our findings suggest that the entorhinal cortex is critical for scene-dependent mnemonic behavior, and the response modality may interact with sensory modality to determine the involvement of the LEC and MEC in scene-based memory tasks.

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Author details

  1. Seung-Woo Yoo

    Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Republic of Korea
    Competing interests
    The authors declare that no competing interests exist.

  2. Inah Lee

    Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Republic of Korea
    For correspondence
    lee.inah@gmail.com
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-3760-4257

Funding

National Research Foundation of Korea (2015M3C7A1031969)

  • Inah Lee

National Research Foundation of Korea (2013R1A1A2062882)

  • Inah Lee

National Research Foundation of Korea (2016R1A2B4008692)

  • Inah Lee

National Research Foundation of Korea (2014051826)

  • Inah Lee

National Research Foundation of Korea (BK21 plus program)

  • Inah Lee

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Ethics

Animal experimentation: This study was performed in strict accordance with the guidelines of the Institutional Animal Care and Use Committee of the Seoul National University. All protocols (SNU-120925-1-7) were in compliance with the Institutional Animal Care and Use Committee of the Seoul National University.

Copyright

© 2017, Yoo & Lee

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Seung-Woo Yoo
  2. Inah Lee
(2017)
Functional double dissociation within the entorhinal cortex for visual scene-dependent choice behavior
eLife 6:e21543.
https://doi.org/10.7554/eLife.21543

Share this article

https://doi.org/10.7554/eLife.21543

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Further reading

    1. Neuroscience

    Interactions between stimulus and response types are more strongly represented in the entorhinal cortex than in its upstream regions in rats

    Eun-Hye Park, Jae-Rong Ahn, Inah Lee
    Research Advance Updated

    Previously we reported results which suggested that response types are critical in dissociating the lateral entorhinal cortex (LEC) from the medial entorhinal cortex (MEC) in a scene memory task (Yoo and Lee, 2017). Here, we investigated whether the perirhinal cortex (PER) and postrhinal cortex (POR), the upstream regions of the LEC and MEC, respectively, could be dissociated similarly. We conducted four tasks by combining different stimulus and response types. Our results suggest that the PER is important whenever object recognition is required and, together with prior findings, imply that PER-LEC networks are essential in goal-directed interactions with objects. The POR appears critical for recognizing visual scenes and may play key roles in scene-based navigation together with the MEC. The relative lack of functional dissociation between stimulus and response types at the PER-POR level suggests that actions conditioned on the recognition of external stimuli may be uniquely represented from the EC.