(A) Custom-made 3D-printed cannula complex. (B) Representative photomicrographs showing the cannula tracks in the LEC (upper left) and MEC (upper right) from the same rat. The numbers denote the relative positions from bregma (mm). (C) Locations of cannula tips of all rats used in the SSC task (n = 8). (D) Locations of cannula tips of all rats used in the SNSC task (n = 9). For LEC cannula locations, red circles indicate medially placed cannula positions in the LEC and blue circles indicate laterally placed cannula positions. The numbers besides the sections denote relative positions of the sections from bregma (mm).
(A) Visual scene stimuli that were used in the SSC task. The two scenes were associated with the left turn, and the other two scenes were associated with the right turn. (B) Post-surgical performance in the SSC task. The MEC-MUS group exhibited significant performance deficits compared to the EC-aCSF and LEC-MUS groups. (C) Performance in the tactile cue-based choice task in the T-maze.
Source data for performance in the SSC task (Figure 2B).
Source data for performance in the tactile-based spatial choice task (Figure 2C).
(A) Visual scene stimuli and their associated choice responses in the SNSC task. (B) Post-surgical performance in the SNSC task. The LEC-MUS condition induced significant performance deficits compared to the EC-aCSF condition. **p<0.01, ***p<0.0001. (C) Rats with the LEC cannulae implanted more medially showed bigger deficits in performance than those with more lateral LEC cannulae, whereas those rats were not different from each other when aCSF was injected.
Source data for performance in the SNSC task (Figure 3B and C).
Ordinate represents the amount of performance difference between aCSF and MUS conditions. *p<0.05, **p<0.001.
(A) In the task, the rats were trained to respond either by digging or pushing the jar based on the magnetic object cue attached to the jar. (B) Post-surgical performance on the task. No significant differences were found between animals in either drug condition.
Source data for performance in the object memory task (Figure 5B).
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Normal performance of rats in the SSC task. Sample trials, each associated with zebra stripes, bamboos, mountains, or pebbles scene are shown in the video.
Performance of rats when injected with aCSF in the EC versus MUS in the LEC in the SNSC task. Scenes are not shown in the video.