Nucleotide and translated amino acid sequence of the reconstructed ancestral HERV-T3 sequence. LTRs are shown in deep blue and bold. The leader sequence is shown in italics and underlined. The pre-gag, gag, pol and env ORFs are indicated in pink, red, green and purple color, respectively. Underlined in green is the sequence overlap between pol and env. The predicted signal peptide and furin cleavage sites are indicated by orange and red triangles, respectively. The predicted fusion peptide, immunosuppressive and transmembrane domains are highlighted in cyan, green and yellow, respectively. The CX6CC motif is indicated with a red box, and the cysteine residues involved in the disulfide-bonded loop are highlighted in red. Cleavage sites were predicted using ProP 1.0.