Epigenetic regulation of lateralized fetal spinal gene expression underlies hemispheric asymmetries
- Ruhr University Bochum, Germany
- St. Johannes Hospital, Germany
- University Hospital Bergmannsheil, Germany
- Max Planck Institute for Psycholinguistics, Netherlands
- Radboud University, Netherlands
- Wallenberg Research Centre at Stellenbosch University, South Africa
Figures
Figure 1
Gene expression asymmetries in human fetal spinal cord at 8, 10 and 12 weeks PC.
X-axis shows the extent of asymmetry measured in log2(fold change) between right and left spinal cord samples. Blue bars show leftward asymmetrically expressed genes, red bars show rightward …
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Figure 1—source data 1
Asymmetrically expressed genes per week.
- https://doi.org/10.7554/eLife.22784.003
Figure 2
Functional genes and gene groups.
(A) Gene expression asymmetries for previously published candidate genes for handedness and functional lateralization. Asterisks indicate biologically relevant gene expression asymmetry with a log2(f…
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Figure 2—source data 1
Enriched GO groups per week and side of the spinal cord.
- https://doi.org/10.7554/eLife.22784.005
Figure 3
Epigenetic regulation of gene expression asymmetries in human fetal spinal cord.
(A) Asymmetrically expressed miRNA transcripts at 8, 10 and 12 weeks PC. The extent of expression asymmetries is measured in log2(fold change). Red bars show rightward asymmetrically expressed …
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Figure 3—source data 1
Asymmetrically expressed miRNAs per week.
- https://doi.org/10.7554/eLife.22784.007
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Figure 3—source data 2
Asymmetrically expressed RNA targets of asymmetrically expressed miRNAs per week.
- https://doi.org/10.7554/eLife.22784.008
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Figure 3—source data 3
Enriched KEGG pathways per week and side of the spinal cord.
- https://doi.org/10.7554/eLife.22784.009
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Figure 3—source data 4
Asymmetrically methylated CpG sites per week and side of the spinal cord.
- https://doi.org/10.7554/eLife.22784.010
Additional files
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Supplementary file 1
(A) Description of tissue samples. (B) RNA quality measurements. (C) DNA quality measurements. (D) RNA read statistics. (E) DNA read statistics. (F) Methylation report. (G) Top 25 asymmetrically expressed genes per sample.
- https://doi.org/10.7554/eLife.22784.011
