Epigenetic regulation of lateralized fetal spinal gene expression underlies hemispheric asymmetries

  1. Sebastian Ocklenburg  Is a corresponding author
  2. Judith Schmitz
  3. Zahra Moinfar
  4. Dirk Moser
  5. Rena Klose
  6. Stephanie Lor
  7. Georg Kunz
  8. Martin Tegenthoff
  9. Pedro Faustmann
  10. Clyde Francks
  11. Jörg T Epplen
  12. Robert Kumsta
  13. Onur Güntürkün
  1. Ruhr University Bochum, Germany
  2. St. Johannes Hospital, Germany
  3. University Hospital Bergmannsheil, Germany
  4. Max Planck Institute for Psycholinguistics, Netherlands
  5. Radboud University, Netherlands
  6. Wallenberg Research Centre at Stellenbosch University, South Africa
3 figures and 1 additional file

Figures

Gene expression asymmetries in human fetal spinal cord at 8, 10 and 12 weeks PC.

X-axis shows the extent of asymmetry measured in log2(fold change) between right and left spinal cord samples. Blue bars show leftward asymmetrically expressed genes, red bars show rightward …

https://doi.org/10.7554/eLife.22784.002
Figure 1—source data 1

Asymmetrically expressed genes per week.

https://doi.org/10.7554/eLife.22784.003
Functional genes and gene groups.

(A) Gene expression asymmetries for previously published candidate genes for handedness and functional lateralization. Asterisks indicate biologically relevant gene expression asymmetry with a log2(f…

https://doi.org/10.7554/eLife.22784.004
Figure 2—source data 1

Enriched GO groups per week and side of the spinal cord.

https://doi.org/10.7554/eLife.22784.005
Epigenetic regulation of gene expression asymmetries in human fetal spinal cord.

(A) Asymmetrically expressed miRNA transcripts at 8, 10 and 12 weeks PC. The extent of expression asymmetries is measured in log2(fold change). Red bars show rightward asymmetrically expressed …

https://doi.org/10.7554/eLife.22784.006
Figure 3—source data 1

Asymmetrically expressed miRNAs per week.

https://doi.org/10.7554/eLife.22784.007
Figure 3—source data 2

Asymmetrically expressed RNA targets of asymmetrically expressed miRNAs per week.

https://doi.org/10.7554/eLife.22784.008
Figure 3—source data 3

Enriched KEGG pathways per week and side of the spinal cord.

https://doi.org/10.7554/eLife.22784.009
Figure 3—source data 4

Asymmetrically methylated CpG sites per week and side of the spinal cord.

https://doi.org/10.7554/eLife.22784.010

Additional files

Supplementary file 1

(A) Description of tissue samples. (B) RNA quality measurements. (C) DNA quality measurements. (D) RNA read statistics. (E) DNA read statistics. (F) Methylation report. (G) Top 25 asymmetrically expressed genes per sample.

https://doi.org/10.7554/eLife.22784.011

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