Node of Ranvier length as a potential regulator of myelinated axon conduction speed
Abstract
Myelination speeds conduction of the nerve impulse, enhancing cognitive power. Changes of white matter structure contribute to learning, and are often assumed to reflect an altered number of myelin wraps. We now show that, in rat optic nerve and cerebral cortical axons, the node of Ranvier length varies over a 4.4-fold and 8.7-fold range respectively and that variation of the node length is much less along axons than between axons. Modelling predicts that these node length differences will alter conduction speed by ~20%, similar to the changes produced by altering the number of myelin wraps or the internode length. For a given change of conduction speed, the membrane area change needed at the node is >270-fold less than that needed in the myelin sheath. Thus, axon-specific adjustment of node of Ranvier length is potentially an energy-efficient and rapid mechanism for tuning the arrival time of information in the CNS.<br /><strong> </strong>
Article and author information
Author details
Funding
Wellcome (099222/Z/12/Z)
- I Lorena Arancibia-Carcamo
- Lee Cossell
- David Attwell
European Commission (623714 AxonGliaPlasticity)
- Marc C Ford
Japan Society for the Promotion of Science London (24650181)
- Kinji Ishida
- Koujiro Tohyama
Japan Society for the Promotion of Science London (25245069)
- Kinji Ishida
- Koujiro Tohyama
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Reviewing Editor
- Klaus-Armin Nave, Max Planck Institute for Experimental Medicine,, Germany
Ethics
Animal experimentation: This work was performed in accordance with the United Kingdom Animals (Scientific Procedures) Act (1986) and subsequent amendments, under UK Home Office licence (PPL 70/7299) and the electrom microscopy part of the work was approved by the Ethical Committee of Iwate Medical University.
Version history
- Received: December 1, 2016
- Accepted: January 24, 2017
- Accepted Manuscript published: January 28, 2017 (version 1)
- Version of Record published: February 16, 2017 (version 2)
Copyright
© 2017, Arancibia-Carcamo et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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