Longevity is impacted by growth hormone action during early postnatal period
- University of Alabama at Birmingham, United States
- Southern Illinois University, School of Medicine, United States
- Leiden University Medical Center, Netherlands
- College of Medicine, University of Central Florida, United States
Abstract
Life-long lack of growth hormone (GH) action can produce remarkable extension of longevity in mice. Here we report that GH treatment limited to a few weeks during development influences the lifespan of long-lived Ames dwarf and normal littermate control mice in a genotype and sex-specific manner. Studies in a separate cohort of Ames dwarf mice show that this short period of the GH exposure during early development produces persistent phenotypic, metabolic and molecular changes that are evident in late adult life. These effects may represent mechanisms responsible for reduced longevity of dwarf mice exposed to GH treatment early in life. Our data suggest that developmental programming of aging importantly contributes to (and perhaps explains) the well documented developmental origins of adult disease.
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Author details
Funding
National Institute on Aging
- Liou Y Sun
National Institute of Diabetes and Digestive and Kidney Diseases
- David B Allison
National Insitute on Aging
- Andrzej Bartke
National Insitute on Aging
- David B Allison
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Animal experimentation: This study was performed in strict accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health. All of the animals were handled according to approved institutional animal care and use committee (IACUC) protocols (IACUC-20292) of the University of Alabama and (#178-020-001) of SIU school of medicine. The protocol was approved by the Committee on the Ethics of Animal Experiments of the UAB and SIUSOM.
Copyright
© 2017, Sun et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Longevity is impacted by growth hormone action during early postnatal period
eLife 6:e24059.
https://doi.org/10.7554/eLife.24059
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