Emergence of visually-evoked reward expectation signals in dopamine neurons via the superior colliculus in V1 lesioned monkeys
- National Institute for Physiological Sciences, Japan
- SOKENDAI, Japan
- Graduate School of Medicine Kyoto University, Japan
- University of Sheffield, United Kingdom
Figures
Figure 1 with 2 supplements
Pavlovian conditioning in V1 lesioned monkeys.
(A) Left: lesion area (depicted in gray) on the whole brain image. Red lines (1 - 3) indicate dorso-ventral levels of horizontal slices shown on the right. Right: lesion area in monkey K (depicted …
Figure 1—figure supplement 1
Unilateral V1 lesion.
(A) Locations of the V1 are shown as red area on the horizontal section traces of monkey K. (B) Traces of horizontal sections of the three monkeys' brain from their MR images. Their lesion areas are …
Figure 1—figure supplement 2
Pavlovian conditioning in monkey U.
Monkey U also provided a confirmatory dataset in the Pavlovian conditioning task. Arrangement of these figures was the same as Figure 1C and F. (A) Licking rates aligned at the CS onset (monkey U). …
Figure 2 with 1 supplement
Effect of SC inactivation on conditioned behaviors.
(A) A scheme of the SC inactivation experiments. Muscimol was injected into the point on the ipsi-lesional SC map representing the location of LR-CS in the visual field. (B) End points of saccadic …
Figure 2—figure supplement 1
Effect of SC inactivation on conditioned behavior in monkey K.
Licking rates in a daily session before (left panel) and after SC inactivation (right panel) in monkey K. Monkey K also provided a confirmatory dataset in the Pavlovian conditioning task before …
Figure 3 with 1 supplement
DA neuron responses during Pavlovian conditioning task.
(A) Schematic drawing of the experimental design for recording DA neuron activity in the monkey with unilateral V1 lesion. (B) Averaged spike waveforms of a presumed DA neuron in SNc and a non-DA …
Figure 3—figure supplement 1
Comparing DA responses to CSs in lesion-affected and intact visual field.
These figures show firing rate of DA response to CS presented into lesion-affected and into intact visual field. Responses to LR-CS were compaired in A, and to SR-CS were in B. Time windows size to …
Figure 4 with 2 supplements
Effect of SC inactivation on cue-responses in DA neurons.
(A) Activity of DA neurons before SC inactivation. Raster plots and firing rates plotted in the same manner as Figure 3F. These plots were aligned at FP onset, at CS onset, and at RW delivery (left, …
Figure 4—figure supplement 1
Spike waveforms of a DA neuron during a daily session.
Comparing the spike waveform of a presumed DA neuron (1) before (black), and (2) soon after muscimol injection (blue) and (3) at the end of recording (green). Averaged spike waveforms obtained from …
Figure 4—figure supplement 2
firing rate of responses to SR-CS.
These figures show firing rate of response to SR-CS before and after muscimol injection (A) and difference of firing rate between responses to LR-CS and to SR-CS during the SC inactivation (time …
