1. Neuroscience
Download icon

Beta band oscillations in motor cortex reflect neural population signals that delay movement onset

  1. Preeya Khanna
  2. Jose M Carmena  Is a corresponding author
  1. University of California, Berkeley, United States
Research Article
  • Cited 31
  • Views 2,349
  • Annotations
Cite this article as: eLife 2017;6:e24573 doi: 10.7554/eLife.24573

Abstract

Motor cortical beta oscillations have been reported for decades, yet their behavioral correlates remain disputed. Some studies link beta oscillations to changes in underlying neural activity, but the specific behavioral manifestations of these reported changes remain elusive. To investigate how changes in population neural activity, beta oscillations, and behavior are linked, we recorded multi-scale neural activity from motor cortex while three macaques performed a novel neurofeedback task. Subjects volitionally brought their beta power to an instructed state and subsequently executed an arm reach. Reaches preceded by a reduction in beta power exhibited significantly faster movement onset times than reaches preceded by an increase in beta power. Further, population neural activity was found to shift farther from a movement onset state during beta oscillations that were neurofeedback-induced or naturally occurring during reaching tasks. This finding establishes a population neural basis for slowing during periods of beta oscillatory activity.

Article and author information

Author details

  1. Preeya Khanna

    UC Berkeley-UCSF Joint Graduate Program in Bioengineering, University of California, Berkeley, Berkeley, United States
    Competing interests
    The authors declare that no competing interests exist.
  2. Jose M Carmena

    UC Berkeley-UCSF Joint Graduate Program in Bioengineering, University of California, Berkeley, Berkeley, United States
    For correspondence
    jcarmena@berkeley.edu
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-0214-2489

Funding

National Science Foundation

  • Preeya Khanna

Defense Sciences Office, DARPA (W911NF-14- 2-0043)

  • Jose M Carmena

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Ethics

Animal experimentation: All procedures were conducted in compliance with the NIH Guide for the Care and Use of Laboratory Animals and were approved by the University of California, Berkeley Institutional Animal Care and Use Committee (protocol AUP-2014-09-6720)

Reviewing Editor

  1. Pascal Fries, Ernst Strüngmann Institute (ESI), Germany

Publication history

  1. Received: December 22, 2016
  2. Accepted: May 1, 2017
  3. Accepted Manuscript published: May 3, 2017 (version 1)
  4. Version of Record published: June 12, 2017 (version 2)

Copyright

© 2017, Khanna & Carmena

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

Metrics

  • 2,349
    Page views
  • 510
    Downloads
  • 31
    Citations

Article citation count generated by polling the highest count across the following sources: Scopus, Crossref, PubMed Central.

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Download citations (links to download the citations from this article in formats compatible with various reference manager tools)

Open citations (links to open the citations from this article in various online reference manager services)

Further reading

    1. Computational and Systems Biology
    2. Neuroscience
    Tuomo Mäki-Marttunen et al.
    Research Article Updated

    Signalling pathways leading to post-synaptic plasticity have been examined in many types of experimental studies, but a unified picture on how multiple biochemical pathways collectively shape neocortical plasticity is missing. We built a biochemically detailed model of post-synaptic plasticity describing CaMKII, PKA, and PKC pathways and their contribution to synaptic potentiation or depression. We developed a statistical AMPA-receptor-tetramer model, which permits the estimation of the AMPA-receptor-mediated maximal synaptic conductance based on numbers of GluR1s and GluR2s predicted by the biochemical signalling model. We show that our model reproduces neuromodulator-gated spike-timing-dependent plasticity as observed in the visual cortex and can be fit to data from many cortical areas, uncovering the biochemical contributions of the pathways pinpointed by the underlying experimental studies. Our model explains the dependence of different forms of plasticity on the availability of different proteins and can be used for the study of mental disorder-associated impairments of cortical plasticity.

    1. Neuroscience
    Kazuki Shiotani et al.
    Research Article Updated

    The ventral tenia tecta (vTT) is a component of the olfactory cortex and receives both bottom-up odor signals and top-down signals. However, the roles of the vTT in odor-coding and integration of inputs are poorly understood. Here, we investigated the involvement of the vTT in these processes by recording the activity from individual vTT neurons during the performance of learned odor-guided reward-directed tasks in mice. We report that individual vTT cells are highly tuned to a specific behavioral epoch of learned tasks, whereby the duration of increased firing correlated with the temporal length of the behavioral epoch. The peak time for increased firing among recorded vTT cells encompassed almost the entire temporal window of the tasks. Collectively, our results indicate that vTT cells are selectively activated during a specific behavioral context and that the function of the vTT changes dynamically in a context-dependent manner during goal-directed behaviors.