Lotka-Volterra pairwise modeling fails to capture diverse pairwise microbial interactions
Abstract
Pairwise models are commonly used to describe many-species communities. In these models, an individual receives additive fitness effects from pairwise interactions with each species in the community ('additivity assumption'). All pairwise interactions are typically represented by a single equation where parameters reflect signs and strengths of fitness effects ('universality assumption'). Here, we show that a single equation fails to qualitatively capture diverse pairwise microbial interactions. We build mechanistic reference models for two microbial species engaging in commonly-found chemical-mediated interactions, and attempt to derive pairwise models. Different equations are appropriate depending on whether a mediator is consumable or reusable, whether an interaction is mediated by one or more mediators, and sometimes even on quantitative details of the community (e.g. relative fitness of the two species, initial conditions). Our results, combined with potential violation of the additivity assumption in many-species communities, suggest that pairwise modeling will often fail to predict microbial dynamics.
Article and author information
Author details
Funding
Boston College
- Babak Momeni
NIH Office of the Director
- Babak Momeni
- Li Xie
- Wenying Shou
W. M. Keck Foundation
- Babak Momeni
- Wenying Shou
Fred Hutchinson Cancer Research Center
- Li Xie
- Wenying Shou
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Reviewing Editor
- Bruce Levin
Version history
- Received: January 11, 2017
- Accepted: March 18, 2017
- Accepted Manuscript published: March 28, 2017 (version 1)
- Accepted Manuscript updated: April 3, 2017 (version 2)
- Version of Record published: June 13, 2017 (version 3)
Copyright
© 2017, Momeni et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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