(A) Flow cytometry analysis of the cellular uptake of dPGS-PTX-IDCC following 5, 10 and 30 min incubation and dPG-PTX-IDCC following 4, 8 and 24 hr incubation in patient-derived glioblastoma cells (hGB1). (B) Flow cytometry analysis of the cellular uptake of dPGS-PTX-IDCC and dPG-PTX-IDCC following treatment with 0.1, 1 and 10 µM P-selectin inhibitor. (C) Internalization of IDCC-labeled dendritic conjugates (blue) into tumor spheroids composed of mCherry-labeled hGB1 cells (red), GFP-labeled HUVEC (green) and astrocytes. (D) Cellular uptake and intracellular trafficking of dPGS-PTX-IDCC and dPG-PTX-IDCC conjugates in U-87 MG cells. The figure depicts representative confocal images of IDCC-labeled dendritic conjugates (cyan), tubulin (green) and the lysosome (red).