Building bridges between cellular and molecular structural biology
- European Bioinformatics Institute, United Kingdom
- FEI Company, France
- University of Helsinki, Finland
- Francis Crick Institute, United Kingdom
- University of Dundee, United Kingdom
- University of Oxford, United Kingdom
- Diamond Light Source Ltd, United Kingdom
- European Molecular Biology Laboratory, European Bioinformatics Institute, United Kingdom
- London Research Institute, United Kingdom
- Leiden University Medical Center, Netherlands
- Lilly UK, United Kingdom
- The State University of New Jersey, United States
- University of Colorado, United States
- Kitware, Inc., United States
- The Francis Crick Institute, United Kingdom
- Janelia Research Campus, Howard Hughes Medical Institute, United States
- Birkbeck College, United Kingdom
- University of Vic - Central University of Catalonia, Spain
- National Cancer Institute, United States
- Science and Technology Facilities Council, United Kingdom
Abstract
The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context. Here we report on the outcomes of a workshop that discussed how to integrate structural data from a range of public archives. The workshop identified two main priorities: the development of tools and file formats to support segmentation (that is, the decomposition of a three-dimensional volume into regions that can be associated with defined objects), and the development of tools to support the annotation of biological structures.
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Funding
Medical Research Council (MR/L007835)
- Gerard J Kleywegt
European Commission (284209)
- Gerard J Kleywegt
Wellcome (104948)
- Gerard J Kleywegt
National Institutes of Health (R01 GM079429)
- Gerard J Kleywegt
Medical Research Council (MR/N009614/1)
- Martyn Winn
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Copyright
This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
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Building bridges between cellular and molecular structural biology
eLife 6:e25835.
https://doi.org/10.7554/eLife.25835
