Building bridges between cellular and molecular structural biology
Abstract
The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context. Here we report on the outcomes of a workshop that discussed how to integrate structural data from a range of public archives. The workshop identified two main priorities: the development of tools and file formats to support segmentation (that is, the decomposition of a three-dimensional volume into regions that can be associated with defined objects), and the development of tools to support the annotation of biological structures.
Article and author information
Author details
Funding
Medical Research Council (MR/L007835)
- Gerard J Kleywegt
European Commission (284209)
- Gerard J Kleywegt
Wellcome (104948)
- Gerard J Kleywegt
National Institutes of Health (R01 GM079429)
- Gerard J Kleywegt
Medical Research Council (MR/N009614/1)
- Martyn Winn
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Reviewing Editor
- Werner Kühlbrandt, Max Planck Institute of Biophysics, Germany
Publication history
- Received: February 8, 2017
- Accepted: June 30, 2017
- Accepted Manuscript published: July 6, 2017 (version 1)
- Version of Record published: July 24, 2017 (version 2)
Copyright
This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
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