(A) The sequence of the light chain of MGD21 with the CDR loops indicated by blue bars. (B) The sequence of the heavy chain of MGD21 aligned to that of germ line LAIR1. Hexagons represent putative glycosyation sites with the red hexagon representing a site lost in MGD21. Yellow circles mark sites in germ line LAIR1 known to affect collagen binding. Red stars represent cysteine residues that make a cross-chain disulphide bond. Residues in the heavy chain are labeled according to whether they derive from the V, J or LAIR1 genes. In both cases, Kabat numbers (Dunbar and Deane, 2016) of residues are given above the sequence. In addition, all the CDRs, with the exception of the third CDR of the heavy chain, are labeled with their canonical class (Martin and Thornton, 1996).