Medial thalamic stroke and its impact on familiarity and recollection

  1. Lola Danet  Is a corresponding author
  2. Jérémie Pariente
  3. Pierre Eustache
  4. Nicolas Raposo
  5. Igor Sibon
  6. Jean-François Albucher
  7. Fabrice Bonneville
  8. Patrice Péran
  9. Emmanuel J Barbeau
  1. Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, France; CHU Toulouse Purpan, Neurology department, Toulouse, France, France
  2. Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, France, France
  3. CHU Toulouse Purpan, Neurology department, Toulouse, France, France
  4. Department of Diagnostic and Therapeutic Neuroimaging, University of Bordeaux Victor Segalen, Bordeaux University Hospital, France, France
  5. Brain and Cognition Research Centre (CerCo), CNRS, University of Toulouse Paul Sabatier, Toulouse, France, France

Abstract

Models of recognition memory have postulated that the mammillo-thalamic tract (MTT) / anterior thalamic nucleus (AN) complex would be critical for recollection while the Mediodorsal nucleus (MD) of the thalamus would support familiarity and indirectly also be involved in recollection (Aggleton et al., 2011). 12 patients with left thalamic stroke underwent a neuropsychological assessment, three verbal recognition memory tasks assessing familiarity and recollection each using different procedures and a high-resolution structural MRI. Patients showed poor recollection on all three tasks. In contrast, familiarity was spared in each task. No patient had significant AN lesions. Critically, a subset of 5 patients had lesions of the MD without lesions of the MTT. They also showed impaired recollection but preserved familiarity. Recollection is therefore impaired following MD damage, but familiarity is not. This suggests that models of familiarity, which assign a critical role to the MD, should be reappraised.

Article and author information

Author details

  1. Lola Danet

    Neurosciences, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, France; CHU Toulouse Purpan, Neurology department, Toulouse, France, Toulouse, France
    For correspondence
    lola.danet@inserm.fr
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-8507-6749
  2. Jérémie Pariente

    Neurosciences, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, France; CHU Toulouse Purpan, Neurology department, Toulouse, France, Toulouse, France
    Competing interests
    The authors declare that no competing interests exist.
  3. Pierre Eustache

    Neurosciences, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, France, Toulouse, France
    Competing interests
    The authors declare that no competing interests exist.
  4. Nicolas Raposo

    Neurosciences, CHU Toulouse Purpan, Neurology department, Toulouse, France, Toulouse, France
    Competing interests
    The authors declare that no competing interests exist.
  5. Igor Sibon

    Neurology, Department of Diagnostic and Therapeutic Neuroimaging, University of Bordeaux Victor Segalen, Bordeaux University Hospital, France, Bordeaux, France
    Competing interests
    The authors declare that no competing interests exist.
  6. Jean-François Albucher

    Neurosciences, CHU Toulouse Purpan, Neurology department, Toulouse, France, Toulouse, France
    Competing interests
    The authors declare that no competing interests exist.
  7. Fabrice Bonneville

    Neurosciences, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, France; CHU Toulouse Purpan, Neurology department, Toulouse, France, Toulouse, France
    Competing interests
    The authors declare that no competing interests exist.
  8. Patrice Péran

    Neurosciences, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, France, Toulouse, France
    Competing interests
    The authors declare that no competing interests exist.
  9. Emmanuel J Barbeau

    Neurosciences, Brain and Cognition Research Centre (CerCo), CNRS, University of Toulouse Paul Sabatier, Toulouse, France, Toulouse, France
    Competing interests
    The authors declare that no competing interests exist.

Funding

Toulouse teaching hospital dedicated grant. (Local funding hospital grant)

  • Jérémie Pariente

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Ethics

Human subjects: All participants provided written informed consent in accordance with the declaration of Helsinki to take part in this study, which was approved by the local institutional review board (Comité de Protection des Personnes Sud-Ouest et Outre-Mer no. 2-11-04).

Copyright

© 2017, Danet et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

Metrics

  • 2,485
    views
  • 222
    downloads
  • 23
    citations

Views, downloads and citations are aggregated across all versions of this paper published by eLife.

Download links

Share this article

https://doi.org/10.7554/eLife.28141

Further reading

    1. Neuroscience
    Jakob Rupert, Dragomir Milovanovic
    Insight

    By influencing calcium homeostasis, local protein synthesis and the endoplasmic reticulum, a small protein called Rab10 emerges as a crucial cytoplasmic regulator of neuropeptide secretion.

    1. Neuroscience
    Yi-Yun Ho, Qiuwei Yang ... Melissa R Warden
    Research Article

    The infralimbic cortex (IL) is essential for flexible behavioral responses to threatening environmental events. Reactive behaviors such as freezing or flight are adaptive in some contexts, but in others a strategic avoidance behavior may be more advantageous. IL has been implicated in avoidance, but the contribution of distinct IL neural subtypes with differing molecular identities and wiring patterns is poorly understood. Here, we study IL parvalbumin (PV) interneurons in mice as they engage in active avoidance behavior, a behavior in which mice must suppress freezing in order to move to safety. We find that activity in inhibitory PV neurons increases during movement to avoid the shock in this behavioral paradigm, and that PV activity during movement emerges after mice have experienced a single shock, prior to learning avoidance. PV neural activity does not change during movement toward cued rewards or during general locomotion in the open field, behavioral paradigms where freezing does not need to be suppressed to enable movement. Optogenetic suppression of PV neurons increases the duration of freezing and delays the onset of avoidance behavior, but does not affect movement toward rewards or general locomotion. These data provide evidence that IL PV neurons support strategic avoidance behavior by suppressing freezing.