Heat stress promotes longevity in budding yeast by relaxing the confinement of age-promoting factors in the mother cell
- Ludwig-Maximilians-University, Germany
- Eidgenössische Technische Hochschule Zürich, Switzerland
Abstract
Although individuals of many species inexorably age, a number of observations established that the rate of ageing is modulated in response to a variety of mild stresses. Here, we investigated how heat stress promotes longevity in yeast. We show that upon growth at higher temperature, yeast cells relax the retention of DNA circles, which act as ageing factors in the mother cell. The enhanced frequency at which circles redistribute to daughter cells was not due to changes of anaphase duration or nuclear shape but solely to the downregulation of the diffusion barrier in the nuclear envelope. This effect depended on the PKA and Tor1 pathways, downstream of stress-response kinase Pkc1. Inhibition of these responses restored barrier function and circle retention and abrogated the effect of heat stress on longevity. Our data indicate that redistribution of ageing factors from aged cells to their progeny can be a mechanism for modulating longevity.
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Author details
Funding
Eidgenössische Technische Hochschule Zürich
- Yves Barral
H2020 European Research Council
- Yves Barral
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Copyright
© 2017, Baldi et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Heat stress promotes longevity in budding yeast by relaxing the confinement of age-promoting factors in the mother cell
eLife 6:e28329.
https://doi.org/10.7554/eLife.28329
