(a, b, c) Radius of gyration (Rg) and (d, e, f) maximum inter-atomic distance (Dmax) plots of the randomly generated pool (solid black) and EOM-selected model (orange) are shown for mUbRab5K116, mUbRab5K140, and mUbRab5K165, respectively. (g, h, i) (Upper) Final ensemble models of mUbRab5K116, mUbRab5K140, and mUbRab5K165. Each EOM-selected ensemble and switch I and II regions of Rab5 (SW I and SW II) are labeled. Rab5 is colored in cyan and ubiquitin is colored in series of red. (Lower) Raw data with the calculated SAXS curve for each model are plotted.