1. Neuroscience
Download icon

Signal integration at spherical bushy cells enhances representation of temporal structure but limits its range

  1. Christian Keine  Is a corresponding author
  2. Rudolf Rübsamen
  3. Bernhard Englitz
  1. University of Leipzig, Germany
  2. Radboud University, Netherlands
Research Advance
  • Cited 10
  • Views 628
  • Annotations
Cite this article as: eLife 2017;6:e29639 doi: 10.7554/eLife.29639

Abstract

Neuronal inhibition is crucial for temporally precise and reproducible signaling in the auditory brainstem.  We showed previously (Keine et al., 2016) that for various synthetic stimuli, spherical bushy cell (SBC) activity in the Mongolian gerbil is rendered sparser and more reliable by subtractive inhibition. Employing environmental stimuli, we demonstrate here that the inhibitory gain control becomes even more effective, keeping stimulated response rates equal to spontaneous ones. However, what are the costs of this modulation? We performed dynamic stimulus reconstructions based on neural population responses for auditory nerve (ANF) input and SBC output to assess the influence of inhibition on signal representation. Compared to ANFs, reconstructions of natural stimuli based on SBC responses were temporally more precise, but the match between acoustic and represented signal decreased. Hence, for natural sounds, inhibition at SBCs plays an even stronger role in achieving sparse and reproducible neuronal activity, while compromising general signal representation.

Article and author information

Author details

  1. Christian Keine

    Faculty of Bioscience, Pharmacy and Psychology, University of Leipzig, Leipzig, Germany
    For correspondence
    christian.keine@gmail.com
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-8953-2593
  2. Rudolf Rübsamen

    Faculty of Bioscience, Pharmacy and Psychology, University of Leipzig, Leipzig, Germany
    Competing interests
    The authors declare that no competing interests exist.
  3. Bernhard Englitz

    Department of Neurophysiology, Donders Center for Neuroscience, Radboud University, Nijmegen, Netherlands
    Competing interests
    The authors declare that no competing interests exist.

Funding

Deutsche Forschungsgemeinschaft (RU 390/19-1)

  • Rudolf Rübsamen

Deutsche Forschungsgemeinschaft (RU 390/20-1)

  • Rudolf Rübsamen

European Commission (Marie Sklodowska Curie Fellowship 660328)

  • Bernhard Englitz

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Ethics

Animal experimentation: Animal experimentation: All experiments were approved by the Saxonian District Government, Leipzig (TVV 06/09), and conducted according to the European Communities Council Directive (86/609/ EEC).

Reviewing Editor

  1. Ian Winter

Publication history

  1. Received: June 23, 2017
  2. Accepted: September 25, 2017
  3. Accepted Manuscript published: September 25, 2017 (version 1)
  4. Version of Record published: October 3, 2017 (version 2)

Copyright

© 2017, Keine et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

Metrics

  • 628
    Page views
  • 93
    Downloads
  • 10
    Citations

Article citation count generated by polling the highest count across the following sources: Scopus, Crossref, PubMed Central.

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Download citations (links to download the citations from this article in formats compatible with various reference manager tools)

Open citations (links to open the citations from this article in various online reference manager services)

Further reading

    1. Neuroscience
    Simon A Sharples, Gareth B Miles
    Research Article Updated

    The size principle underlies the orderly recruitment of motor units; however, motoneuron size is a poor predictor of recruitment amongst functionally defined motoneuron subtypes. Whilst intrinsic properties are key regulators of motoneuron recruitment, the underlying currents involved are not well defined. Whole-cell patch-clamp electrophysiology was deployed to study intrinsic properties, and the underlying currents, that contribute to the differential activation of delayed and immediate firing motoneuron subtypes. Motoneurons were studied during the first three postnatal weeks in mice to identify key properties that contribute to rheobase and may be important to establish orderly recruitment. We find that delayed and immediate firing motoneurons are functionally homogeneous during the first postnatal week and are activated based on size, irrespective of subtype. The rheobase of motoneuron subtypes becomes staggered during the second postnatal week, which coincides with the differential maturation of passive and active properties, particularly persistent inward currents. Rheobase of delayed firing motoneurons increases further in the third postnatal week due to the development of a prominent resting hyperpolarization-activated inward current. Our results suggest that motoneuron recruitment is multifactorial, with recruitment order established during postnatal development through the differential maturation of passive properties and sequential integration of persistent and hyperpolarization-activated inward currents.

    1. Neuroscience
    P Christiaan Klink et al.
    Research Article Updated

    Population receptive field (pRF) modeling is a popular fMRI method to map the retinotopic organization of the human brain. While fMRI-based pRF maps are qualitatively similar to invasively recorded single-cell receptive fields in animals, it remains unclear what neuronal signal they represent. We addressed this question in awake nonhuman primates comparing whole-brain fMRI and large-scale neurophysiological recordings in areas V1 and V4 of the visual cortex. We examined the fits of several pRF models based on the fMRI blood-oxygen-level-dependent (BOLD) signal, multi-unit spiking activity (MUA), and local field potential (LFP) power in different frequency bands. We found that pRFs derived from BOLD-fMRI were most similar to MUA-pRFs in V1 and V4, while pRFs based on LFP gamma power also gave a good approximation. fMRI-based pRFs thus reliably reflect neuronal receptive field properties in the primate brain. In addition to our results in V1 and V4, the whole-brain fMRI measurements revealed retinotopic tuning in many other cortical and subcortical areas with a consistent increase in pRF size with increasing eccentricity, as well as a retinotopically specific deactivation of default mode network nodes similar to previous observations in humans.