(A) Power spectrum density (PSD) curves of CA1 local field potentials (LFP) during linear track exploration showed no significant differences between Dp(16)1Yey and WT mice, including in the theta (6–12 Hz), beta (15–30 Hz) and gamma bands (30–100 Hz). (B) The number of spikes plotted as a function of the phase of theta showed a similar pattern between WT and Dp(16)1Yey mice, peaking shortly after the trough of theta (black curve). (C) The preferred firing phase was calculated for significantly theta-modulated neuron during the exploration phase in the linear track and plotted in a circular histogram. No significant differences were observed between Dp(16)1Yey and WT groups, with a preferred phase of theta around 215–240° (0/360° set for theta peak, 180° for theta trough). (D) The von Mises κ parameter revealed no significant differences in the concentration of firings across the theta cycle between Dp(16)1Yey and WT. No group differences where observed in average pyramidal cell Kullback-Leibler divergence (E) and modulation index (F). Values are expressed as mean ±standard error of the mean. Statistical significance was assessed using ANOVA for repeated measures (A), circular ANOVA (B), Kuiper test (C) or Mann-Whitney U-test (D–F) with significance set at p<0.05.