(A) Performance deficits (calculated by subtracting the ACSF-based performance from the MUS-based performance) in the nonspatial response tasks (Mean ± SEM). The POR-MUS condition resulted in significant deficits in performance when scenes were used as cues, but not when objects were used. The PER-MUS condition produced deficits in using scenes and objects for making nonspatial choices with bigger deficits with object cues. (B) Performance deficits in the spatial response tasks (Mean ± SEM). Both PER-MUS and POR-MUS conditioned produced similar levels of impairment observed in the nonspatial tasks (A), suggesting the lack of scene-response interaction at the PER and POR level. Furthermore, the more prominent roles of the PER, but not the POR, in the object-cued task was also observed in the spatial response tasks. *p<0.025. (C) A working model for information processing in the medial temporal lobe. Multimodal sensory inputs (VIS: visual, OLF: olfactory, AUD: auditory, SOM: somatosensory) are provided to the PER, and only visual inputs are fed to the POR. The PER and POR process these inputs to recognize objects and scenes, respectively. The LEC is involved in remembering choice responses associated with objects, whereas the MEC represents navigation-related variables using visual scene information from the POR. The LEC is reciprocally connected to the PER, hippocampus, insular cortex, and frontal areas (Burwell and Amaral, 1998a). Also, the LEC projects to the basal ganglia, medial prefrontal cortex, somatosensory cortex, and motor areas (Swanson and Köhler, 1986). The MEC has reciprocal connections with the POR, hippocampus, cingulate, and parietal cortex (Burwell and Amaral, 1998b). The MEC receives projections from the parasubiculum and postsubiculum (Canto et al., 2008). In this model, the PER-LEC networks are to interact with objects and the POR-MEC networks process information to navigate in space. In the hippocampus, the neural representations from these two channels are temporally structured with relative values in a goal-directed manner to generate rich episodic memories.