Interactions between stimulus and response types are more strongly represented in the entorhinal cortex than in its upstream regions in rats

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Abstract

Previously we reported results which suggested that response types are critical in dissociating the lateral entorhinal cortex (LEC) from the medial entorhinal cortex (MEC) in a scene memory task (Yoo and Lee, 2017). Here, we investigated whether the perirhinal cortex (PER) and postrhinal cortex (POR), the upstream regions of the LEC and MEC, respectively, could be dissociated similarly. We conducted four tasks by combining different stimulus and response types. Our results suggest that the PER is important whenever object recognition is required and, together with prior findings, imply that PER-LEC networks are essential in goal-directed interactions with objects. The POR appears critical for recognizing visual scenes and may play key roles in scene-based navigation together with the MEC. The relative lack of functional dissociation between stimulus and response types at the PER-POR level suggests that actions conditioned on the recognition of external stimuli may be uniquely represented from the EC.

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Eun-Hye Park

Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Republic of Korea

Competing interests
The authors declare that no competing interests exist.
Jae-Rong Ahn

Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Republic of Korea

Competing interests
The authors declare that no competing interests exist.
Inah Lee

Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Republic of Korea

For correspondence
inahlee@snu.ac.kr

Competing interests
The authors declare that no competing interests exist.

"This ORCID iD identifies the author of this article:" 0000-0003-3760-4257

Funding

National Research Foundation of Korea (2015M3C7A1031969)

Inah Lee

National Research Foundation of Korea (2016R1A2B4008692)

Inah Lee

National Research Foundation of Korea (2017M3C7A1029661)

Inah Lee

National Research Foundation of Korea (5286-2014100 (BK21+ program))

Inah Lee

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Ethics

Animal experimentation: All of the animals were handled according to approved institutional animal care and use committee (IACUC) protocols of the Seoul National University (SNU-120925-1-7). All surgery was performed under isoflurane anesthesia, and every effort was made to minimize suffering.

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This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.