Developmental deprivation-induced perceptual and cortical processing deficits in awake-behaving animals
- New York University, United States
- NYU Langone Medical Center, United States
Figures
Figure 1
Developmental conductive hearing loss impairs AM rate detection.
(A) Psychometric functions across four tested AM rates (64, 128, 256, and 512 Hz) from a single testing session for a representative Ctl (black) and HL (orange) animal. (B) Average temporal …
Figure 2
Gerbils did not use an average level cue.
Average d’ across 12 dB SPL sound levels from 4 Ctl animals tested at 64, 128, 256, and 512 Hz AM rates. Mean ± SEM.
Figure 3
HL-related AM detection deficits cannot be explained by elevated ABR thresholds.
(A) Click ABR thresholds from Ctl (black) and HL (orange) animals. ABR thresholds from HL animals were significantly greater than those from Ctl animals (**p<0.0001). Horizontal bars represent the …
Figure 4
HL-related AM detection deficits cannot be explained by brainstem temporal processing.
(A,B) Example click-evoked ABR traces across dB SPL recorded with separate electrode positions. Vertical dashed-line indicates stimulus onset. (C,D) Representative EFR to 64 Hz (C) and 512 Hz (D) AM …
Figure 5
Candidate waveform selection for neurometric analyses.
(A) Schematic of AM stimuli. For a majority of sessions, unmodulated and AM stimuli had a 200 ms onset ramp, followed by an unmodulated period of 200 ms that would maintain as unmodulated or …
Figure 6 with 1 supplement
Cortical representation of fast AM rates.
(A) Cumulative distributions of maximum stimulus-driven FR (left), spontaneous FR (middle), and CV (FR standard deviation/average FR; right) for Ctl (black) and HL (orange) units. Inset: …
Figure 6—figure supplement 1
Multi- and single-unit data were analyzed separately with a bootstrapped statistical procedure.
https://doi.org/10.7554/eLife.33891.008
Figure 7
ACx population decoder analysis can explain HL-related behavioral deficits.
(A) Assessing population encoding by measuring discriminability with a linear population readout. Hypothetical population responses for single trials of a Nogo (red) and Go (black) stimulus. Spikes …
Figure 8
Monotonically increasing versus monotonically decreasing units.
(A) Distribution of monotonicity index (MI) values from all Ctl (black) and HL (orange) units across 64, 128, 256, and 512 Hz AM rate conditions. Solid vertical red line represents the …
Figure 9
Summary of psychometric, EFR, and cortical threshold values.
Solid lines represent behavior thresholds. Dashed lines represent EFR thresholds. Dotted lines represent ACx population decoder thresholds. Ctl ACx population threshold at 256 Hz was taken as the …
Author response image 1
Preliminary assessment of head position.
No difference in neural responses for separate nosepoke and reward apparatus locations was observed in these two example ACx units.
Additional files
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Transparent reporting form
- https://doi.org/10.7554/eLife.33891.012
