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Ultra-Rapid serial visual presentation reveals dynamics of feedforward and feedback processes in the ventral visual pathway

  1. Yalda Mohsenzadeh
  2. Sheng Qin
  3. Radoslaw M Cichy
  4. Dimitrios Pantazis  Is a corresponding author
  1. Massachusetts Institute of Technology, United States
  2. Free University of Berlin, Germany
Research Article
  • Cited 12
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Cite this article as: eLife 2018;7:e36329 doi: 10.7554/eLife.36329

Abstract

Human visual recognition activates a dense network of overlapping feedforward and recurrent neuronal processes, making it hard to disentangle processing in the feedforward from the feedback direction. Here, we used ultra-rapid serial visual presentation to suppress sustained activity that blurs the boundaries of processing steps, enabling us to resolve two distinct stages of processing with MEG multivariate pattern classification. The first processing stage was the rapid activation cascade of the bottom-up sweep, which terminated early as visual stimuli were presented at progressively faster rates. The second stage was the emergence of categorical information with peak latency that shifted later in time with progressively faster stimulus presentations, indexing time-consuming recurrent processing. Using MEG-fMRI fusion with representational similarity, we localized recurrent signals in early visual cortex. Together, our findings segregated an initial bottom-up sweep from subsequent feedback processing, and revealed the neural signature of increased recurrent processing demands for challenging viewing conditions.

Article and author information

Author details

  1. Yalda Mohsenzadeh

    McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-8525-957X
  2. Sheng Qin

    McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United States
    Competing interests
    The authors declare that no competing interests exist.
  3. Radoslaw M Cichy

    Education and Psychology, Free University of Berlin, Berlin, Germany
    Competing interests
    The authors declare that no competing interests exist.
  4. Dimitrios Pantazis

    McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United States
    For correspondence
    pantazis@mit.edu
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-8246-8878

Funding

McGovern Institute (Neurotechnology Program)

  • Dimitrios Pantazis

Emmy Noether Award (CI241/1-1)

  • Radoslaw M Cichy

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Ethics

Human subjects: The study was approved by the Institutional Review Board of the Massachusetts Institute of Technology and followed the principles of the Declaration of Helsinki. All subjects signed an informed consent form and were compensated for their participation.

Reviewing Editor

  1. Floris P de Lange, Donders Institute for Brain, Cognition and Behaviour, Netherlands

Publication history

  1. Received: March 1, 2018
  2. Accepted: June 16, 2018
  3. Accepted Manuscript published: June 21, 2018 (version 1)
  4. Version of Record published: July 3, 2018 (version 2)

Copyright

© 2018, Mohsenzadeh et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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