We report the near atomic resolution (3.3 Å) of the human polycystic kidney disease 2-like 1 (polycystin 2-l1) ion channel. Encoded by PKD2L1, polycystin 2-l1 is a calcium and monovalent cation-permeant ion channel in primary cilia and plasma membranes. The related primary cilium-specific polycystin-2 protein, encoded by PKD2, shares a high degree of sequence similarity, yet has distinct permeability characteristics. Here we show that these differences are reflected in the architecture of polycystin 2-l1.
The cryo map and model have been deposited to the Worldwide Protein Data Bank (6DU8) and Electron Microscopy Data Bank (8912).
Cryo map and model fromPublicly available at the Worldwide Protein Data Bank (Accession no: 6DU8).
Cryo map and model fromPublicly available at the Electron Microscopy Data Bank (Accession no: 8912).
- David E Clapham
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
- Baron Chanda, University of Wisconsin-Madison, United States
© 2018, Hulse et al.
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