Within-session responding during test session, presented in 1 min time bins. Responding in all conditions was minimal during minute 10 and has been excluded. Error bars depict + SEM. There were significant devaluation effects in both lesion conditions, however they were expressed differently over time. Specifically, the devaluation effect was more persistent across time in the Lesion groups than the Sham groups. A mixed Lesion (sham, lesion) x Devaluation (devalued, non-devalued) x Bin (9 bins of 1 min) ANOVA revealed a main effect of Devaluation (F(1, 28)=5.03, p=0.03), Bin (F(8, 224)=16.74, p<0.001) and Lesion x Devaluation x Bin interaction (F(8, 224)=2.53, p=0.01) (All remaining Fs <1.47, p>0.17). Follow up Devaluation x Bin ANOVAs for each lesion group revealed a significant main effect of Devaluation (F(1, 14)=4.81, p=0.046) and Bin (F(8, 112)=12.05, p<0.001) but no Devaluation x Bin interaction (F(8, 112)=1.32, p=0.24) for the Lesion group. In contrast, Sham group showed a significant main effect of Bin (F(8, 112)=6.98, p<0.001) and Devaluation x Bin interaction (F(8, 112)=2.66, p=0.01, and a significant Devaluation x Bin linear trend interaction F(1, 14)=6.97, p=0.02), but no significant main effect of Devaluation (F(1, 14)=0.79, p=0.39). Bonferroni corrected simple effects revealed significantly higher responding in the Non-Devalued Sham group than the Devalued Sham Group during the 7th minute (F(1, 14)=12.19, p=0.004, all remaining minutes failed to reach significance, Fs <2.73, p>0.12). Linear trend contrasts revealed significant negative linear decreases in lever responding over time Bins in the Sham Devalued group (F(1, 7)=126.03, p<0.001), but not the Sham Non-Devalued group (F(1, 7)=3.36, p=0.109). (*) Symbol denotes statistical significance of simple or main effects following a significant interaction.