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Consolidation alters motor sequence-specific distributed representations

  1. Basile Pinsard  Is a corresponding author
  2. Arnaud Boutin
  3. Ella Gabitov
  4. Ovidiu Lungu
  5. Habib Benali
  6. Julien Doyon  Is a corresponding author
  1. Sorbonne Université, CNRS, INSERM, France
  2. Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Canada
  3. McGill University, Canada
  4. Concordia University, Canada
Research Article
Cite this article as: eLife 2019;8:e39324 doi: 10.7554/eLife.39324
8 figures, 1 data set and 7 additional files

Figures

Figure 1 with 1 supplement
Correct sequence durations (average and standard error of the mean across participants) across the MVPA task blocks.
https://doi.org/10.7554/eLife.39324.002
Figure 1—figure supplement 1
Sequence duration of trained sequences in the first blocks for each sequence on the last experimental day (mean and standard error across participants).
https://doi.org/10.7554/eLife.39324.003
Figure 2 with 4 supplements
Group searchlight conjunction of new and consolidated sequences discriminability maps (z-score thresholded at p < .05 TFCE-cluster-corrected) showing a large distributed set of cortical regions showing sequence disciminative patterns at both learning stages.

Regions of interest with Freesurfer colors: Acc.:Accumbens; Put.:Putamen; Caud.:Caudate; Pal.:Pallidum; vDC:ventral diencephalon; Am.:Amygdala; Hc.:Hippocampus; Thal.:Thalamus; Cb.:Cerebellum; BS:brain-stem.

https://doi.org/10.7554/eLife.39324.004
Figure 2—figure supplement 1
Group searchlight map of cross-validated Mahalanobis distance between the two new sequences (z-score thresholded at p < .05 TFCE-cluster-corrected).
https://doi.org/10.7554/eLife.39324.005
Figure 2—figure supplement 2
Group searchlight map of cross-validated Mahalanobis distance between the two consolidated sequences (z-score thresholded at p < .05 TFCE-cluster-corrected).
https://doi.org/10.7554/eLife.39324.006
Figure 2—figure supplement 3
Main effect of motor sequence execution during MVPA task.

(t-value thresholded at p < 05 FDR-corrected).

https://doi.org/10.7554/eLife.39324.007
Figure 2—figure supplement 4
Illustration of the method: for each neighborhood centered on a gray-matter coordinate, we computed cross-validated Mahalanobis distance matrices.

The two maps of interest, respectively representing the distances between new sequences and between consolidated sequences, were then analyzed at the group level.

https://doi.org/10.7554/eLife.39324.008
Conjunction of group searchlight contrast (paired t-test) between consolidated and new sequences discriminability maps and separate group discriminability maps for new and consolidated sequences (z-score thresholded at p < .05 TFCE-cluster-corrected) showing a reorganization of the distributed memory trace between these two stages.

Acc.:Accumbens; Put.:Putamen; Caud.:Caudate; Pal.:Pallidum; vDC:ventral diencephalon; Am.:Amygdala; Hc.:Hippocampus; Thal.:Thalamus; Cb.:Cerebellum; BS:brain-stem.

https://doi.org/10.7554/eLife.39324.010
Author response image 1
Contrast between within-trained and within-consolidated sequence mahalanobis distances in the second acquisition run (p<.05 Monte-Carlo TFCE corrected).
Author response image 2
Contrast (run2-run1) between new sequences Mahalanobis distances (p<.05 Monte-Carlo TFCE corrected).
Author response image 3
Main effect of motor sequence execution during MVPA task.

(t-value thresholded at p<.05 FDR-corrected).

Author response image 4
Conjunction of Consolidated>New contrast map and exclusive disjunction of Consolidate>0 and New>0 maps (p<.05 Monte-Carlo TFCE corrected).
Author response image 5
Sequence duration of Trained sequences in the first blocks for each sequence on the last experimental day (mean and standard error across participants).

Data availability

Behavioral data analyzed and presented in the article as well as statistical maps of brain representational measure have been deposited on the Open Science Framework with the DOI 10.17605/OSF.IO/EPJ2V

The following data sets were generated
  1. 1
    Open Science Framework
    1. B Pinsard
    (2018)
    Consolidation alters motor sequence-specific distributed representations.

Additional files

Supplementary file 1

Test for differences in speed (mean duration to perform a correct sequence) per block between trained and new sequences.

https://doi.org/10.7554/eLife.39324.012
Supplementary file 2

Test for differences in accuracy (number of correct sequences over the five repetitions in a block) between trained and new sequences.

https://doi.org/10.7554/eLife.39324.013
Supplementary file 3

Test for differences in speed and accuracy between the new sequences.

https://doi.org/10.7554/eLife.39324.014
Supplementary file 4

Test for differences in speed and accuracy between the consolidated sequences.

https://doi.org/10.7554/eLife.39324.015
Source code 1

MNI coordinates of main-effect clusters center-of-mass.

https://doi.org/10.7554/eLife.39324.016
Source code 2

MNI coordinates of contrast clusters center-of-mass.

https://doi.org/10.7554/eLife.39324.017
Transparent reporting form
https://doi.org/10.7554/eLife.39324.018

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