Consolidation alters motor sequence-specific distributed representations
- Sorbonne Université, CNRS, INSERM, France
- Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Canada
- McGill University, Canada
- Concordia University, Canada
Figures
Figure 1 with 1 supplement
Correct sequence durations (average and standard error of the mean across participants) across the MVPA task blocks.
https://doi.org/10.7554/eLife.39324.002
Figure 1—figure supplement 1
Sequence duration of trained sequences in the first blocks for each sequence on the last experimental day (mean and standard error across participants).
https://doi.org/10.7554/eLife.39324.003
Figure 2 with 4 supplements
Group searchlight conjunction of new and consolidated sequences discriminability maps (z-score thresholded at p < .05 TFCE-cluster-corrected) showing a large distributed set of cortical regions showing sequence disciminative patterns at both learning stages.
Regions of interest with Freesurfer colors: Acc.:Accumbens; Put.:Putamen; Caud.:Caudate; Pal.:Pallidum; vDC:ventral diencephalon; Am.:Amygdala; Hc.:Hippocampus; Thal.:Thalamus; Cb.:Cerebellum; BS:brain-stem.
Figure 2—figure supplement 1
Group searchlight map of cross-validated Mahalanobis distance between the two new sequences (z-score thresholded at p < .05 TFCE-cluster-corrected).
https://doi.org/10.7554/eLife.39324.005
Figure 2—figure supplement 2
Group searchlight map of cross-validated Mahalanobis distance between the two consolidated sequences (z-score thresholded at p < .05 TFCE-cluster-corrected).
https://doi.org/10.7554/eLife.39324.006
Figure 2—figure supplement 3
Main effect of motor sequence execution during MVPA task.
(t-value thresholded at p < 05 FDR-corrected).
Figure 2—figure supplement 4
Illustration of the method: for each neighborhood centered on a gray-matter coordinate, we computed cross-validated Mahalanobis distance matrices.
The two maps of interest, respectively representing the distances between new sequences and between consolidated sequences, were then analyzed at the group level.
Figure 3
Conjunction of group searchlight contrast (paired t-test) between consolidated and new sequences discriminability maps and separate group discriminability maps for new and consolidated sequences (z-score thresholded at p < .05 TFCE-cluster-corrected) showing a reorganization of the distributed memory trace between these two stages.
Acc.:Accumbens; Put.:Putamen; Caud.:Caudate; Pal.:Pallidum; vDC:ventral diencephalon; Am.:Amygdala; Hc.:Hippocampus; Thal.:Thalamus; Cb.:Cerebellum; BS:brain-stem.
Author response image 1
Contrast between within-trained and within-consolidated sequence mahalanobis distances in the second acquisition run (p<.05 Monte-Carlo TFCE corrected).
Author response image 2
Contrast (run2-run1) between new sequences Mahalanobis distances (p<.05 Monte-Carlo TFCE corrected).
Author response image 3
Main effect of motor sequence execution during MVPA task.
(t-value thresholded at p<.05 FDR-corrected).
Author response image 4
Conjunction of Consolidated>New contrast map and exclusive disjunction of Consolidate>0 and New>0 maps (p<.05 Monte-Carlo TFCE corrected).
Author response image 5
Sequence duration of Trained sequences in the first blocks for each sequence on the last experimental day (mean and standard error across participants).
Additional files
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Supplementary file 1
Test for differences in speed (mean duration to perform a correct sequence) per block between trained and new sequences.
- https://doi.org/10.7554/eLife.39324.012
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Supplementary file 2
Test for differences in accuracy (number of correct sequences over the five repetitions in a block) between trained and new sequences.
- https://doi.org/10.7554/eLife.39324.013
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Supplementary file 3
Test for differences in speed and accuracy between the new sequences.
- https://doi.org/10.7554/eLife.39324.014
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Supplementary file 4
Test for differences in speed and accuracy between the consolidated sequences.
- https://doi.org/10.7554/eLife.39324.015
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Source code 1
MNI coordinates of main-effect clusters center-of-mass.
- https://doi.org/10.7554/eLife.39324.016
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Source code 2
MNI coordinates of contrast clusters center-of-mass.
- https://doi.org/10.7554/eLife.39324.017
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Transparent reporting form
- https://doi.org/10.7554/eLife.39324.018
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Consolidation alters motor sequence-specific distributed representations
eLife 8:e39324.
https://doi.org/10.7554/eLife.39324
