A Phytophthora effector recruits a host cytoplasmic transacetylase into nuclear speckles to enhance plant susceptibility
- Nanjing Agriculture University, China
- Oregon State University, United States
Abstract
Oomycete pathogens secrete host cell-entering effector proteins to manipulate host immunity during infection. We previously showed that PsAvh52, an early-induced RxLR effector secreted from the soybean root rot pathogen, Phytophthora sojae, could suppress plant immunity. Here, we found that PsAvh52 is required for full virulence on soybean and binds to a novel soybean transacetylase, GmTAP1, in vivo and in vitro. PsAvh52 could cause GmTAP1 to relocate into the nucleus where GmTAP1 could acetylate histones H2A and H3 during early infection, thereby promoting susceptibility to P. sojae. In the absence of PsAvh52, GmTAP1 remained confined to the cytoplasm and did not modify plant susceptibility. These results demonstrate that GmTAP1 is a susceptibility factor that is hijacked by PsAvh52 in order to promote epigenetic modifications that enhance the susceptibility of soybean to P. sojae infection.
Data availability
All data generated or analysed during this study are included in the manuscript and supporting files
Article and author information
Author details
Funding
Creative Research Groups of the National Natural Science Foundation of China (31721004)
- Yuanchao Wang
The Special Fund for Agro-scientific Research in the Public Interest (201303018)
- Yuanchao Wang
The China Agriculture Research System (CARS-004-PS14)
- Yuanchao Wang
The Key Programme of the National Natural Science Foundation of China (31430073)
- Yuanchao Wang
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Reviewing Editor
- Jian-Min Zhou, Chinese Academy of Sciences, China
Version history
- Received: July 13, 2018
- Accepted: October 21, 2018
- Accepted Manuscript published: October 22, 2018 (version 1)
- Version of Record published: November 21, 2018 (version 2)
Copyright
© 2018, Li et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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A Phytophthora effector recruits a host cytoplasmic transacetylase into nuclear speckles to enhance plant susceptibility
eLife 7:e40039.
https://doi.org/10.7554/eLife.40039
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