Meiotic drive of female-inherited supernumerary chromosomes in a pathogenic fungus

  1. Michael Habig
  2. Gert Kema
  3. Eva Holtgrewe Stukenbrock  Is a corresponding author
  1. Christian-Albrechts University of Kiel, Germany
  2. Wageningen UR, Netherlands

Abstract

Meiosis is a key cellular process of sexual reproduction involving the pairing of homologous sequences. In many species however, meiosis can also involve the segregation of supernumerary chromosomes, which can lack a homolog. How these unpaired chromosomes undergo meiosis is largely unknown. In this study we investigated chromosome segregation during meiosis in the haploid fungus Zymoseptoria tritici that possesses a large complement of supernumerary chromosomes. We used isogenic whole chromosome deletion strains to compare meiotic transmission of chromosomes when paired and unpaired. Unpaired chromosomes inherited from the male parent as well as paired supernumerary chromosomes in general showed Mendelian inheritance. In contrast, unpaired chromosomes inherited from the female parent showed non-Mendelian inheritance but were amplified and transmitted to all meiotic products. We concluded that the supernumerary chromosomes of Z. tritici show a meiotic drive and propose an additional feedback mechanism during meiosis which initiates amplification of unpaired female-inherited chromosomes.

Data availability

Sequencing reads have been deposited in the Sequence Read Archive and are available under the BioProject PRJNA438050. These datasets will be made public upon acceptance of manuscript. All data generated or analysed during this study are included in the manuscript and supporting files (Supplementary Files 2-4). Source data files have been provided for Figures 2 and Figure 2—figure supplement 1.

The following data sets were generated

Article and author information

Author details

  1. Michael Habig

    Environmental Genomics, Christian-Albrechts University of Kiel, Ploen, Germany
    Competing interests
    The authors declare that no competing interests exist.
  2. Gert Kema

    Wageningen Plant Research, Wageningen UR, Wageningen, Netherlands
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-2732-6911
  3. Eva Holtgrewe Stukenbrock

    Environmental Genomics, Christian-Albrechts University of Kiel, Ploen, Germany
    For correspondence
    stukenbrock@evolbio.mpg.de
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-8590-3345

Funding

State of Schleswig Holstein

  • Eva Holtgrewe Stukenbrock

Max-Planck-Gesellschaft (Open-access funding)

  • Eva Holtgrewe Stukenbrock

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Reviewing Editor

  1. Antonis Rokas, Vanderbilt University, United States

Publication history

  1. Received: July 20, 2018
  2. Accepted: December 12, 2018
  3. Accepted Manuscript published: December 13, 2018 (version 1)
  4. Version of Record published: January 14, 2019 (version 2)

Copyright

© 2018, Habig et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Michael Habig
  2. Gert Kema
  3. Eva Holtgrewe Stukenbrock
(2018)
Meiotic drive of female-inherited supernumerary chromosomes in a pathogenic fungus
eLife 7:e40251.
https://doi.org/10.7554/eLife.40251

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